Prospective Study of BK Virus Infection in Patients with Inflammatory Bowel Disease
Patients with inflammatory bowel disease (IBD) have an immune-deficient baseline status further modulated by immunosuppressive therapy that may promote the reactivation of latent viruses such as BK virus (BKV). The aim of this prospective study was to determine the prevalence of BKV infection in IBD...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/970528 |
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| _version_ | 1832558315999068160 |
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| author | Virginia Flores Belén Rodríguez-Sánchez Ignacio Marín-Jiménez Emilio Bouza Luis Menchén Patricia Muñoz |
| author_facet | Virginia Flores Belén Rodríguez-Sánchez Ignacio Marín-Jiménez Emilio Bouza Luis Menchén Patricia Muñoz |
| author_sort | Virginia Flores |
| collection | DOAJ |
| description | Patients with inflammatory bowel disease (IBD) have an immune-deficient baseline status further modulated by immunosuppressive therapy that may promote the reactivation of latent viruses such as BK virus (BKV). The aim of this prospective study was to determine the prevalence of BKV infection in IBD patients and its potential relationship with the immunosuppressive treatment. Paired urine and plasma samples from 53 consecutive patients with IBD and 53 controls were analyzed. BKV detection was performed by conventional PCR and positive samples were further quantified by real-time PCR. No viremia was detected. BKV viruria was significantly more common in IBD patients than among the controls (54.7% versus 11.3%; P<0.0001). The only risk factor for BKV viruria in IBD was age (47.2±16.3 versus 37.8±15.2; P=0.036), and there was a trend towards higher rate of viruria in outpatients (61.5% versus 38.5%; P=0.096) and in those not receiving ciprofloxacin (59.5% versus 40.5%; P=0.17). A clear impact of the immunosuppressive regimen on BKV infection could not be demonstrated. |
| format | Article |
| id | doaj-art-522b3f5f44f44b2d8f6fd60fd4df1cc0 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-522b3f5f44f44b2d8f6fd60fd4df1cc02025-02-03T01:32:44ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/970528970528Prospective Study of BK Virus Infection in Patients with Inflammatory Bowel DiseaseVirginia Flores0Belén Rodríguez-Sánchez1Ignacio Marín-Jiménez2Emilio Bouza3Luis Menchén4Patricia Muñoz5Department of Digestive Diseases, General University Hospital Gregorio Marañón, Dr. Esquerdo 46, 28007 Madrid, SpainDepartment of Clinical Microbiology and Infectious Diseases, General University Hospital Gregorio Marañón, Dr. Esquerdo 46, 28007 Madrid, SpainDepartment of Digestive Diseases, General University Hospital Gregorio Marañón, Dr. Esquerdo 46, 28007 Madrid, SpainDepartment of Clinical Microbiology and Infectious Diseases, General University Hospital Gregorio Marañón, Dr. Esquerdo 46, 28007 Madrid, SpainDepartment of Digestive Diseases, General University Hospital Gregorio Marañón, Dr. Esquerdo 46, 28007 Madrid, SpainDepartment of Clinical Microbiology and Infectious Diseases, General University Hospital Gregorio Marañón, Dr. Esquerdo 46, 28007 Madrid, SpainPatients with inflammatory bowel disease (IBD) have an immune-deficient baseline status further modulated by immunosuppressive therapy that may promote the reactivation of latent viruses such as BK virus (BKV). The aim of this prospective study was to determine the prevalence of BKV infection in IBD patients and its potential relationship with the immunosuppressive treatment. Paired urine and plasma samples from 53 consecutive patients with IBD and 53 controls were analyzed. BKV detection was performed by conventional PCR and positive samples were further quantified by real-time PCR. No viremia was detected. BKV viruria was significantly more common in IBD patients than among the controls (54.7% versus 11.3%; P<0.0001). The only risk factor for BKV viruria in IBD was age (47.2±16.3 versus 37.8±15.2; P=0.036), and there was a trend towards higher rate of viruria in outpatients (61.5% versus 38.5%; P=0.096) and in those not receiving ciprofloxacin (59.5% versus 40.5%; P=0.17). A clear impact of the immunosuppressive regimen on BKV infection could not be demonstrated.http://dx.doi.org/10.1155/2014/970528 |
| spellingShingle | Virginia Flores Belén Rodríguez-Sánchez Ignacio Marín-Jiménez Emilio Bouza Luis Menchén Patricia Muñoz Prospective Study of BK Virus Infection in Patients with Inflammatory Bowel Disease The Scientific World Journal |
| title | Prospective Study of BK Virus Infection in Patients with Inflammatory Bowel Disease |
| title_full | Prospective Study of BK Virus Infection in Patients with Inflammatory Bowel Disease |
| title_fullStr | Prospective Study of BK Virus Infection in Patients with Inflammatory Bowel Disease |
| title_full_unstemmed | Prospective Study of BK Virus Infection in Patients with Inflammatory Bowel Disease |
| title_short | Prospective Study of BK Virus Infection in Patients with Inflammatory Bowel Disease |
| title_sort | prospective study of bk virus infection in patients with inflammatory bowel disease |
| url | http://dx.doi.org/10.1155/2014/970528 |
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