How can mathematics be used to improve burn care?
Severe second-degree ‘partial thickness’ and third-degree ‘full thickness’ burns are characterized by damage to the dermal layer of the skin. In the dermis, specialized cells called fibroblasts play a crucial role in wound healing. These cells produce collagen, a protein that provides strength and s...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Burns Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468912224000786 |
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| author | Ginger Egberts Fred Vermolen Qiyao Peng H.Ibrahim Korkmaz Paul van Zuijlen |
| author_facet | Ginger Egberts Fred Vermolen Qiyao Peng H.Ibrahim Korkmaz Paul van Zuijlen |
| author_sort | Ginger Egberts |
| collection | DOAJ |
| description | Severe second-degree ‘partial thickness’ and third-degree ‘full thickness’ burns are characterized by damage to the dermal layer of the skin. In the dermis, specialized cells called fibroblasts play a crucial role in wound healing. These cells produce collagen, a protein that provides strength and structure to the skin. After burn injury, fibroblasts migrate to the injured area and start producing and depositing collagen to help repair the damaged tissue. While contraction is essential for closing the wound, it can also result in scar contraction (contractures), especially in more severe burns. This contraction creates stresses on the skin, which can deteriorate the mobility of joints near the burn.This article overviews the most recent research results in computer simulations of scar contraction after burns. |
| format | Article |
| id | doaj-art-52232b8e0d3b4d689e387c7d96db917c |
| institution | Kabale University |
| issn | 2468-9122 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Burns Open |
| spelling | doaj-art-52232b8e0d3b4d689e387c7d96db917c2025-01-19T06:26:27ZengElsevierBurns Open2468-91222025-01-019100390How can mathematics be used to improve burn care?Ginger Egberts0Fred Vermolen1Qiyao Peng2H.Ibrahim Korkmaz3Paul van Zuijlen4Computational Mathematics Group, Department of Mathematics and Statistics, University of Hasselt, Diepenbeek, Belgium; Dutch Burn Foundation, Beverwijk, the Netherlands; Department of Plastic, Reconstructive and Hand Surgery, Amsterdam UMC, Location VUmc, Amsterdam Movement Sciences, Amsterdam, the Netherlands; Corresponding author at: Computational Mathematics Group, Department of Mathematics and Statistics, University of Hasselt, Diepenbeek, Belgium.Computational Mathematics Group, Department of Mathematics and Statistics, University of Hasselt, Diepenbeek, Belgium; Data Science Institute (DSI), University of Hasselt, Hasselt, BelgiumMathematical Institute, University of Leiden, Leiden, the Netherlands; Bioinformatics, Department of Computer Science, Vrije Universiteit Amsterdam, Amsterdam, the NetherlandsBurn Center, Department of Plastic, Reconstructive and Hand Surgery, Red Cross Hospital, Beverwijk, the Netherlands; Department of Plastic, Reconstructive and Hand Surgery, Amsterdam UMC, Location VUmc, Amsterdam Movement Sciences, Amsterdam, the Netherlands; Department of Molecular Cell Biology and Immunology, Amsterdam UMC, Location VUmc, Amsterdam, the NetherlandsBurn Center, Department of Plastic, Reconstructive and Hand Surgery, Red Cross Hospital, Beverwijk, the Netherlands; Pediatric Surgical Centre, Emma Children’s Hospital, Amsterdam UMC, Location AMC and VUmc, Amsterdam, the NetherlandsSevere second-degree ‘partial thickness’ and third-degree ‘full thickness’ burns are characterized by damage to the dermal layer of the skin. In the dermis, specialized cells called fibroblasts play a crucial role in wound healing. These cells produce collagen, a protein that provides strength and structure to the skin. After burn injury, fibroblasts migrate to the injured area and start producing and depositing collagen to help repair the damaged tissue. While contraction is essential for closing the wound, it can also result in scar contraction (contractures), especially in more severe burns. This contraction creates stresses on the skin, which can deteriorate the mobility of joints near the burn.This article overviews the most recent research results in computer simulations of scar contraction after burns.http://www.sciencedirect.com/science/article/pii/S2468912224000786Post-burn contractionMathematical modelsAgent-based modelsContinuum modelsParameter uncertaintyArtificial intelligence |
| spellingShingle | Ginger Egberts Fred Vermolen Qiyao Peng H.Ibrahim Korkmaz Paul van Zuijlen How can mathematics be used to improve burn care? Burns Open Post-burn contraction Mathematical models Agent-based models Continuum models Parameter uncertainty Artificial intelligence |
| title | How can mathematics be used to improve burn care? |
| title_full | How can mathematics be used to improve burn care? |
| title_fullStr | How can mathematics be used to improve burn care? |
| title_full_unstemmed | How can mathematics be used to improve burn care? |
| title_short | How can mathematics be used to improve burn care? |
| title_sort | how can mathematics be used to improve burn care |
| topic | Post-burn contraction Mathematical models Agent-based models Continuum models Parameter uncertainty Artificial intelligence |
| url | http://www.sciencedirect.com/science/article/pii/S2468912224000786 |
| work_keys_str_mv | AT gingeregberts howcanmathematicsbeusedtoimproveburncare AT fredvermolen howcanmathematicsbeusedtoimproveburncare AT qiyaopeng howcanmathematicsbeusedtoimproveburncare AT hibrahimkorkmaz howcanmathematicsbeusedtoimproveburncare AT paulvanzuijlen howcanmathematicsbeusedtoimproveburncare |