Effects of Acute Normovolemic Anemia on Hemodynamic Parameters and Acid-Base Balance in Dogs
The aim of this study was to evaluate the hemodynamic and acid-base status of dogs subjected to acute normovolemic anemia. The dogs (n=10) were evaluated 15 minutes and 24 hours after induction of anemia (hematocrit below 18%) with blood withdrawal and simultaneously replacement of same volume of Ri...
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Wiley
2011-01-01
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| Series: | Veterinary Medicine International |
| Online Access: | http://dx.doi.org/10.4061/2011/829054 |
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| author | Tatiana Champion Glaucia Bueno Pereira Neto Aparecido Antonio Camacho |
| author_facet | Tatiana Champion Glaucia Bueno Pereira Neto Aparecido Antonio Camacho |
| author_sort | Tatiana Champion |
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| description | The aim of this study was to evaluate the hemodynamic and acid-base status of dogs subjected to acute normovolemic anemia. The dogs (n=10) were evaluated 15 minutes and 24 hours after induction of anemia (hematocrit below 18%) with blood withdrawal and simultaneously replacement of same volume of Ringer's lactate solution and hydroxyethyl starch-based solution in a 2 : 1 ratio. The cardiac output was measured by Doppler echocardiography and blood pressure by oscillometric device, and posteriorly hemodynamic parameters were calculated. The anemic groups had increase in cardiac index (P<.05) (3.82±1.05 to 5.86±1.49 and 5.81±1.63 L/min × m2) and decreases (P<.05) in the indices of total peripheral resistance (6797.81±3060.22 to 3220.14±1275.02 and 3887.74±1394.89 dina⋅seg/cm5 × m2) and oxygen delivery (7942.84±3344.00 to 4021.68±1627.00 and 4430.82±1402.61 mL/min × m2), respectively. There were no significant changes in pH, but PaO2 and SaO2 values were increased, and PaCO2 reduced in anemic dogs (P<.05). Therefore, acute normovolemic anemia can create significant hemodynamic changes and despite some hemogasometric changes, there were no changes in the acid-base status in dogs. |
| format | Article |
| id | doaj-art-5221cfe589584ecd9fb09e6814698a0c |
| institution | Kabale University |
| issn | 2042-0048 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Veterinary Medicine International |
| spelling | doaj-art-5221cfe589584ecd9fb09e6814698a0c2025-02-03T01:30:08ZengWileyVeterinary Medicine International2042-00482011-01-01201110.4061/2011/829054829054Effects of Acute Normovolemic Anemia on Hemodynamic Parameters and Acid-Base Balance in DogsTatiana Champion0Glaucia Bueno Pereira Neto1Aparecido Antonio Camacho2Department of Animal Surgery and Clinical Sciences, Faculty of Agricultural and Veterinary Sciences (FCAV), São Paulo State University (UNESP), Via de Acesso Professor Paulo Donato Castellane, km 5, 14884-900 Jaboticabal, SP, BrazilDepartment of Animal Surgery and Clinical Sciences, Faculty of Agricultural and Veterinary Sciences (FCAV), São Paulo State University (UNESP), Via de Acesso Professor Paulo Donato Castellane, km 5, 14884-900 Jaboticabal, SP, BrazilDepartment of Animal Surgery and Clinical Sciences, Faculty of Agricultural and Veterinary Sciences (FCAV), São Paulo State University (UNESP), Via de Acesso Professor Paulo Donato Castellane, km 5, 14884-900 Jaboticabal, SP, BrazilThe aim of this study was to evaluate the hemodynamic and acid-base status of dogs subjected to acute normovolemic anemia. The dogs (n=10) were evaluated 15 minutes and 24 hours after induction of anemia (hematocrit below 18%) with blood withdrawal and simultaneously replacement of same volume of Ringer's lactate solution and hydroxyethyl starch-based solution in a 2 : 1 ratio. The cardiac output was measured by Doppler echocardiography and blood pressure by oscillometric device, and posteriorly hemodynamic parameters were calculated. The anemic groups had increase in cardiac index (P<.05) (3.82±1.05 to 5.86±1.49 and 5.81±1.63 L/min × m2) and decreases (P<.05) in the indices of total peripheral resistance (6797.81±3060.22 to 3220.14±1275.02 and 3887.74±1394.89 dina⋅seg/cm5 × m2) and oxygen delivery (7942.84±3344.00 to 4021.68±1627.00 and 4430.82±1402.61 mL/min × m2), respectively. There were no significant changes in pH, but PaO2 and SaO2 values were increased, and PaCO2 reduced in anemic dogs (P<.05). Therefore, acute normovolemic anemia can create significant hemodynamic changes and despite some hemogasometric changes, there were no changes in the acid-base status in dogs.http://dx.doi.org/10.4061/2011/829054 |
| spellingShingle | Tatiana Champion Glaucia Bueno Pereira Neto Aparecido Antonio Camacho Effects of Acute Normovolemic Anemia on Hemodynamic Parameters and Acid-Base Balance in Dogs Veterinary Medicine International |
| title | Effects of Acute Normovolemic Anemia on Hemodynamic Parameters and Acid-Base Balance in Dogs |
| title_full | Effects of Acute Normovolemic Anemia on Hemodynamic Parameters and Acid-Base Balance in Dogs |
| title_fullStr | Effects of Acute Normovolemic Anemia on Hemodynamic Parameters and Acid-Base Balance in Dogs |
| title_full_unstemmed | Effects of Acute Normovolemic Anemia on Hemodynamic Parameters and Acid-Base Balance in Dogs |
| title_short | Effects of Acute Normovolemic Anemia on Hemodynamic Parameters and Acid-Base Balance in Dogs |
| title_sort | effects of acute normovolemic anemia on hemodynamic parameters and acid base balance in dogs |
| url | http://dx.doi.org/10.4061/2011/829054 |
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