Association of aggregate index of systemic inflammation with increased all-cause and cardiovascular mortality in female cancer patients
BackgroundCancer is a leading cause of death, especially among women, with cancers like breast, ovarian, and cervical cancer presenting unique diagnostic and treatment challenges. Systemic inflammation plays a significant role in cancer progression, affecting both tumor development and therapeutic o...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1552341/full |
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| author | Ying Yang Ying Yang Zelin Hu Yuqin Ye Haoqi Wu Wei Sun Ning Wang |
| author_facet | Ying Yang Ying Yang Zelin Hu Yuqin Ye Haoqi Wu Wei Sun Ning Wang |
| author_sort | Ying Yang |
| collection | DOAJ |
| description | BackgroundCancer is a leading cause of death, especially among women, with cancers like breast, ovarian, and cervical cancer presenting unique diagnostic and treatment challenges. Systemic inflammation plays a significant role in cancer progression, affecting both tumor development and therapeutic outcomes. Despite the established link between inflammation and cancer, comprehensive studies on the prognostic value of the Aggregate Index of Systemic Inflammation (AISI) in female cancer patients are lacking. This study explores the association between AISI and mortality outcomes, including all-cause and cardiovascular mortality, in female cancer patients.MethodsThis study analyzes data from the NHANES database and Dandong Central Hospital. Kaplan-Meier survival curves and multivariable Cox proportional hazards regression analyses were used to assess the relationship between AISI and all-cause and cardiovascular mortality. Restricted cubic spline plots and subgroup analyses were applied to explore potential interactions.ResultsElevated AISI levels were strongly associated with increased all-cause and cardiovascular mortality. Patients in the highest AISI quartile demonstrated significantly higher mortality risks compared to those in the lowest quartile. ROC curve analysis indicated superior predictive performance of AISI over SII. Restricted cubic spline plots revealed a linear relationship, with mortality risk notably increasing when AISI levels were elevated.ConclusionAISI is a robust predictor of all-cause and cardiovascular mortality in female cancer patients. Its ease of measurement and strong prognostic value make it a valuable tool for risk assessment and management in this population. |
| format | Article |
| id | doaj-art-521f2bc43a454d8c8a57dfccdfdcc4a9 |
| institution | OA Journals |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-521f2bc43a454d8c8a57dfccdfdcc4a92025-08-20T02:29:30ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-04-011510.3389/fonc.2025.15523411552341Association of aggregate index of systemic inflammation with increased all-cause and cardiovascular mortality in female cancer patientsYing Yang0Ying Yang1Zelin Hu2Yuqin Ye3Haoqi Wu4Wei Sun5Ning Wang6Dalian Medical University, Dalian, ChinaThe Dandong Central Hospital, Dandong, ChinaThe Second Hospital of Dalian Medical University, Dalian, ChinaMedical College of Wuhan University of Science and Technology, Wuhan, ChinaThe Second Hospital of Dalian Medical University, Dalian, ChinaThe Dandong Central Hospital, Dandong, ChinaThe Second Hospital of Dalian Medical University, Dalian, ChinaBackgroundCancer is a leading cause of death, especially among women, with cancers like breast, ovarian, and cervical cancer presenting unique diagnostic and treatment challenges. Systemic inflammation plays a significant role in cancer progression, affecting both tumor development and therapeutic outcomes. Despite the established link between inflammation and cancer, comprehensive studies on the prognostic value of the Aggregate Index of Systemic Inflammation (AISI) in female cancer patients are lacking. This study explores the association between AISI and mortality outcomes, including all-cause and cardiovascular mortality, in female cancer patients.MethodsThis study analyzes data from the NHANES database and Dandong Central Hospital. Kaplan-Meier survival curves and multivariable Cox proportional hazards regression analyses were used to assess the relationship between AISI and all-cause and cardiovascular mortality. Restricted cubic spline plots and subgroup analyses were applied to explore potential interactions.ResultsElevated AISI levels were strongly associated with increased all-cause and cardiovascular mortality. Patients in the highest AISI quartile demonstrated significantly higher mortality risks compared to those in the lowest quartile. ROC curve analysis indicated superior predictive performance of AISI over SII. Restricted cubic spline plots revealed a linear relationship, with mortality risk notably increasing when AISI levels were elevated.ConclusionAISI is a robust predictor of all-cause and cardiovascular mortality in female cancer patients. Its ease of measurement and strong prognostic value make it a valuable tool for risk assessment and management in this population.https://www.frontiersin.org/articles/10.3389/fonc.2025.1552341/fullfemale canceraggregate index of systemic inflammationAISImortalityNHANES |
| spellingShingle | Ying Yang Ying Yang Zelin Hu Yuqin Ye Haoqi Wu Wei Sun Ning Wang Association of aggregate index of systemic inflammation with increased all-cause and cardiovascular mortality in female cancer patients Frontiers in Oncology female cancer aggregate index of systemic inflammation AISI mortality NHANES |
| title | Association of aggregate index of systemic inflammation with increased all-cause and cardiovascular mortality in female cancer patients |
| title_full | Association of aggregate index of systemic inflammation with increased all-cause and cardiovascular mortality in female cancer patients |
| title_fullStr | Association of aggregate index of systemic inflammation with increased all-cause and cardiovascular mortality in female cancer patients |
| title_full_unstemmed | Association of aggregate index of systemic inflammation with increased all-cause and cardiovascular mortality in female cancer patients |
| title_short | Association of aggregate index of systemic inflammation with increased all-cause and cardiovascular mortality in female cancer patients |
| title_sort | association of aggregate index of systemic inflammation with increased all cause and cardiovascular mortality in female cancer patients |
| topic | female cancer aggregate index of systemic inflammation AISI mortality NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1552341/full |
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