Preclinical systematic review of CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents

Preclinical systematic review of CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents

C-C chemokine receptor type 5 (CCR5) antagonists may improve both acute stroke outcome and long-term recovery. Despite their evaluation in ongoing clinical trials, gaps remain in the evidence supporting their use. With a panel of patients with lived experiences of stroke, we performed a systematic r...

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Bibliographic Details
Main Authors: Ayni Sharif, Matthew S Jeffers, Dean A Fergusson, Raj Bapuji, Stuart G Nicholls, John Humphrey, Warren Johnston, Ed Mitchell, Mary-Ann Speirs, Laura Stronghill, Michele Vuckovic, Susan Wulf, Risa Shorr, Dar Dowlatshahi, Dale Corbett, Manoj M Lalu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-04-01
Series:eLife
Subjects:
stroke
neuroprotection
maraviroc
preclinical
patient engagement
CCR5
Online Access:https://elifesciences.org/articles/103245
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