Effects of 1 565 nm non-ablative fractional laser combined with intense pulsed light on post-acne erythema and skin barrier function
[Objective] To explore the effect of 1 565 nm non-ablative fractional laser combined with intense pulsed light on post-acne erythema and skin barrier function. [Methods] A total of 156 patients with post acne erythema (PAE) who were treated in our hospital from March 2021 to March 2024 were screened...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology
2025-07-01
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| Series: | Pifu-xingbing zhenliaoxue zazhi |
| Subjects: | |
| Online Access: | http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2025.07.006 |
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| Summary: | [Objective] To explore the effect of 1 565 nm non-ablative fractional laser combined with intense pulsed light on post-acne erythema and skin barrier function. [Methods] A total of 156 patients with post acne erythema (PAE) who were treated in our hospital from March 2021 to March 2024 were screened. Patients were divided into control group (n=76) and combination group (n=80) according to their willingness to the treatment. The control group received 1 565 nm non-ablative fractional laser treatment, while the combination group received additional intense pulsed light therapy on top of the control treatment. Using R software, propensity score matching was performed between the two groups using the caliper matching method at a 1 ∶1 ratio, resulting in 50 patients in each group. The clinical efficacy, erythema index, and skin barrier function, including transdermal water loss (TEWL), pH, a value, lactate acid sting test score, protein content in the tape strip, stratum corneum water content and self-satisfaction of patients were compared between the two groups after the treatment. Difference-in-differences model was used to analyze the effects of combined therapy on self-satisfaction score and erythema index. [Results] Two months after the treatment, the total effective rate of the combined group (98.00%) was significantly higher than that of the control group (78.00%). The erythema index (185.53±36.65 vs. 216.05±42.59), TEWL (18.23±3.12 vs. 19.75±3.09) and a value (14.98±1.83 vs. 19.63±2.18), lactic acid sting test score (1.85±0.75 vs. 3.28±1.10), and protein content in the tape strip (29.23±6.38 vs. 35.05±7.26) were significantly lower in the combined group than in control group. In contrast, both stratum corneum water content and self-satisfaction score were significantly higher in the combined group than in the controls (49.26±4.98 vs. 38.32±4.82 for water content; 4.63±1.75 vs. 3.75±1.59 for satisfaction score. P<0.05 for both). The results of difference-in-differences analysis showed that the increase in self-satisfaction scores after treatment was 1.367 points higher in the combination group than in the control group, and the reduction in erythema index was 12.167 points greater, indicating a significant therapeutic effect. [Conclusions] Following treatment with 1 565 nm non-ablative fractional laser combined with intense pulsed light, patients show a reduction in erythema index, improvement in skin barrier function and patient self-satisfaction scores. |
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| ISSN: | 1674-8468 |