Metabolic Context Regulates Distinct Hypothalamic Transcriptional Responses to Antiaging Interventions
The hypothalamus is an essential relay in the neural circuitry underlying energy metabolism that needs to continually adapt to changes in the energetic environment. The neuroendocrine control of food intake and energy expenditure is associated with, and likely dependent upon, hypothalamic plasticity...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2012/732975 |
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| author | Alexis M. Stranahan Bronwen Martin Wayne Chadwick Sung-Soo Park Liyun Wang Kevin G. Becker William H. WoodIII Yongqing Zhang Stuart Maudsley |
| author_facet | Alexis M. Stranahan Bronwen Martin Wayne Chadwick Sung-Soo Park Liyun Wang Kevin G. Becker William H. WoodIII Yongqing Zhang Stuart Maudsley |
| author_sort | Alexis M. Stranahan |
| collection | DOAJ |
| description | The hypothalamus is an essential relay in the neural circuitry underlying energy metabolism that needs to continually adapt to changes in the energetic environment. The neuroendocrine control of food intake and energy expenditure is associated with, and likely dependent upon, hypothalamic plasticity. Severe disturbances in energy metabolism, such as those that occur in obesity, are therefore likely to be associated with disruption of hypothalamic transcriptomic plasticity. In this paper, we investigated the effects of two well-characterized antiaging interventions, caloric restriction and voluntary wheel running, in two distinct physiological paradigms, that is, diabetic (db/db) and nondiabetic wild-type (C57/Bl/6) animals to investigate the contextual sensitivity of hypothalamic transcriptomic responses. We found that, both quantitatively and qualitatively, caloric restriction and physical exercise were associated with distinct transcriptional signatures that differed significantly between diabetic and non-diabetic mice. This suggests that challenges to metabolic homeostasis regulate distinct hypothalamic gene sets in diabetic and non-diabetic animals. A greater understanding of how genetic background contributes to hypothalamic response mechanisms could pave the way for the development of more nuanced therapeutics for the treatment of metabolic disorders that occur in diverse physiological backgrounds. |
| format | Article |
| id | doaj-art-520b344bbf0c4126aa0e2edeecf432c6 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-520b344bbf0c4126aa0e2edeecf432c62025-02-03T01:04:57ZengWileyInternational Journal of Endocrinology1687-83371687-83452012-01-01201210.1155/2012/732975732975Metabolic Context Regulates Distinct Hypothalamic Transcriptional Responses to Antiaging InterventionsAlexis M. Stranahan0Bronwen Martin1Wayne Chadwick2Sung-Soo Park3Liyun Wang4Kevin G. Becker5William H. WoodIII6Yongqing Zhang7Stuart Maudsley8Physiology Department, Georgia Health Sciences University, Augusta, GA 30912, USAMetabolism Unit, National Institute on Aging Intramural Research Program, Baltimore, MD 21224-6825, USAReceptor Pharmacology Unit, National Institute on Aging Intramural Research Program, Baltimore, MD 21224-6825, USAReceptor Pharmacology Unit, National Institute on Aging Intramural Research Program, Baltimore, MD 21224-6825, USAReceptor Pharmacology Unit, National Institute on Aging Intramural Research Program, Baltimore, MD 21224-6825, USAGene Expression and Genomics Unit, National Institute on Aging Intramural Research Program, Baltimore, MD 21224-6825, USAGene Expression and Genomics Unit, National Institute on Aging Intramural Research Program, Baltimore, MD 21224-6825, USAGene Expression and Genomics Unit, National Institute on Aging Intramural Research Program, Baltimore, MD 21224-6825, USAReceptor Pharmacology Unit, National Institute on Aging Intramural Research Program, Baltimore, MD 21224-6825, USAThe hypothalamus is an essential relay in the neural circuitry underlying energy metabolism that needs to continually adapt to changes in the energetic environment. The neuroendocrine control of food intake and energy expenditure is associated with, and likely dependent upon, hypothalamic plasticity. Severe disturbances in energy metabolism, such as those that occur in obesity, are therefore likely to be associated with disruption of hypothalamic transcriptomic plasticity. In this paper, we investigated the effects of two well-characterized antiaging interventions, caloric restriction and voluntary wheel running, in two distinct physiological paradigms, that is, diabetic (db/db) and nondiabetic wild-type (C57/Bl/6) animals to investigate the contextual sensitivity of hypothalamic transcriptomic responses. We found that, both quantitatively and qualitatively, caloric restriction and physical exercise were associated with distinct transcriptional signatures that differed significantly between diabetic and non-diabetic mice. This suggests that challenges to metabolic homeostasis regulate distinct hypothalamic gene sets in diabetic and non-diabetic animals. A greater understanding of how genetic background contributes to hypothalamic response mechanisms could pave the way for the development of more nuanced therapeutics for the treatment of metabolic disorders that occur in diverse physiological backgrounds.http://dx.doi.org/10.1155/2012/732975 |
| spellingShingle | Alexis M. Stranahan Bronwen Martin Wayne Chadwick Sung-Soo Park Liyun Wang Kevin G. Becker William H. WoodIII Yongqing Zhang Stuart Maudsley Metabolic Context Regulates Distinct Hypothalamic Transcriptional Responses to Antiaging Interventions International Journal of Endocrinology |
| title | Metabolic Context Regulates Distinct Hypothalamic Transcriptional Responses to Antiaging Interventions |
| title_full | Metabolic Context Regulates Distinct Hypothalamic Transcriptional Responses to Antiaging Interventions |
| title_fullStr | Metabolic Context Regulates Distinct Hypothalamic Transcriptional Responses to Antiaging Interventions |
| title_full_unstemmed | Metabolic Context Regulates Distinct Hypothalamic Transcriptional Responses to Antiaging Interventions |
| title_short | Metabolic Context Regulates Distinct Hypothalamic Transcriptional Responses to Antiaging Interventions |
| title_sort | metabolic context regulates distinct hypothalamic transcriptional responses to antiaging interventions |
| url | http://dx.doi.org/10.1155/2012/732975 |
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