Human Liver-Derived Stem Cells Improve Fibrosis and Inflammation Associated with Nonalcoholic Steatohepatitis
Cell therapy may be regarded as a feasible alternative to whole organ transplantation to treat end-stage liver diseases. Human liver stem cells (HLSCs) are a population of cells easily obtainable and expandable from a human adult liver biopsy. HLSCs share with mesenchymal stromal cells the same phen...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2019/6351091 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548882667536384 |
|---|---|
| author | Stefania Bruno Maria Beatriz Herrera Sanchez Chiara Pasquino Marta Tapparo Massimo Cedrino Ciro Tetta Giovanni Camussi |
| author_facet | Stefania Bruno Maria Beatriz Herrera Sanchez Chiara Pasquino Marta Tapparo Massimo Cedrino Ciro Tetta Giovanni Camussi |
| author_sort | Stefania Bruno |
| collection | DOAJ |
| description | Cell therapy may be regarded as a feasible alternative to whole organ transplantation to treat end-stage liver diseases. Human liver stem cells (HLSCs) are a population of cells easily obtainable and expandable from a human adult liver biopsy. HLSCs share with mesenchymal stromal cells the same phenotype, gene expression profile, and differentiation capabilities. In addition, HLSCs show a specific commitment to the hepatic phenotype. Injection of HLSCs into immunodeficient mice fed with a methionine-choline-deficient diet to induce nonalcoholic steatohepatitis ameliorates liver function and morphology. In particular, HLSC treatment induced a reduction of liver fibrosis and inflammation at morphological and molecular levels. Moreover, HLSCs were able to persist for up to 3 weeks after the injection. In conclusion, HLSCs have healing effects in a model of chronic liver disease. |
| format | Article |
| id | doaj-art-5207ac19e859425cb43dd2904b07334b |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-5207ac19e859425cb43dd2904b07334b2025-02-03T06:12:48ZengWileyStem Cells International1687-966X1687-96782019-01-01201910.1155/2019/63510916351091Human Liver-Derived Stem Cells Improve Fibrosis and Inflammation Associated with Nonalcoholic SteatohepatitisStefania Bruno0Maria Beatriz Herrera Sanchez1Chiara Pasquino2Marta Tapparo3Massimo Cedrino4Ciro Tetta5Giovanni Camussi6Department of Medical Sciences, University of Torino, Torino, ItalyMolecular Biotechnology Centre, University of Torino, Torino, ItalyMolecular Biotechnology Centre, University of Torino, Torino, ItalyDepartment of Medical Sciences, University of Torino, Torino, ItalyMolecular Biotechnology Centre, University of Torino, Torino, ItalyUnicyte Srl, Torino, ItalyDepartment of Medical Sciences, University of Torino, Torino, ItalyCell therapy may be regarded as a feasible alternative to whole organ transplantation to treat end-stage liver diseases. Human liver stem cells (HLSCs) are a population of cells easily obtainable and expandable from a human adult liver biopsy. HLSCs share with mesenchymal stromal cells the same phenotype, gene expression profile, and differentiation capabilities. In addition, HLSCs show a specific commitment to the hepatic phenotype. Injection of HLSCs into immunodeficient mice fed with a methionine-choline-deficient diet to induce nonalcoholic steatohepatitis ameliorates liver function and morphology. In particular, HLSC treatment induced a reduction of liver fibrosis and inflammation at morphological and molecular levels. Moreover, HLSCs were able to persist for up to 3 weeks after the injection. In conclusion, HLSCs have healing effects in a model of chronic liver disease.http://dx.doi.org/10.1155/2019/6351091 |
| spellingShingle | Stefania Bruno Maria Beatriz Herrera Sanchez Chiara Pasquino Marta Tapparo Massimo Cedrino Ciro Tetta Giovanni Camussi Human Liver-Derived Stem Cells Improve Fibrosis and Inflammation Associated with Nonalcoholic Steatohepatitis Stem Cells International |
| title | Human Liver-Derived Stem Cells Improve Fibrosis and Inflammation Associated with Nonalcoholic Steatohepatitis |
| title_full | Human Liver-Derived Stem Cells Improve Fibrosis and Inflammation Associated with Nonalcoholic Steatohepatitis |
| title_fullStr | Human Liver-Derived Stem Cells Improve Fibrosis and Inflammation Associated with Nonalcoholic Steatohepatitis |
| title_full_unstemmed | Human Liver-Derived Stem Cells Improve Fibrosis and Inflammation Associated with Nonalcoholic Steatohepatitis |
| title_short | Human Liver-Derived Stem Cells Improve Fibrosis and Inflammation Associated with Nonalcoholic Steatohepatitis |
| title_sort | human liver derived stem cells improve fibrosis and inflammation associated with nonalcoholic steatohepatitis |
| url | http://dx.doi.org/10.1155/2019/6351091 |
| work_keys_str_mv | AT stefaniabruno humanliverderivedstemcellsimprovefibrosisandinflammationassociatedwithnonalcoholicsteatohepatitis AT mariabeatrizherrerasanchez humanliverderivedstemcellsimprovefibrosisandinflammationassociatedwithnonalcoholicsteatohepatitis AT chiarapasquino humanliverderivedstemcellsimprovefibrosisandinflammationassociatedwithnonalcoholicsteatohepatitis AT martatapparo humanliverderivedstemcellsimprovefibrosisandinflammationassociatedwithnonalcoholicsteatohepatitis AT massimocedrino humanliverderivedstemcellsimprovefibrosisandinflammationassociatedwithnonalcoholicsteatohepatitis AT cirotetta humanliverderivedstemcellsimprovefibrosisandinflammationassociatedwithnonalcoholicsteatohepatitis AT giovannicamussi humanliverderivedstemcellsimprovefibrosisandinflammationassociatedwithnonalcoholicsteatohepatitis |