Pharmacological Inactivation of Src Family Kinases Inhibits LPS-Induced TNF-α Production in PBMC of Patients with Behçet’s Disease
Behçet’s disease (BD) is a multisystemic chronic inflammatory disease characterized by relapsing oral and genital ulcers, uveitis, and skin lesions. The pathogenesis of BD is still unknown. Aberrant production of some cytokines/chemokines plays an important role in the pathogenesis of various inflam...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/5414369 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832558795196203008 |
|---|---|
| author | Sevgi Irtegun Gulsum Pektanc Zeynep M. Akkurt Mehtap Bozkurt Fatih M. Turkcu Sevgi Kalkanli-Tas |
| author_facet | Sevgi Irtegun Gulsum Pektanc Zeynep M. Akkurt Mehtap Bozkurt Fatih M. Turkcu Sevgi Kalkanli-Tas |
| author_sort | Sevgi Irtegun |
| collection | DOAJ |
| description | Behçet’s disease (BD) is a multisystemic chronic inflammatory disease characterized by relapsing oral and genital ulcers, uveitis, and skin lesions. The pathogenesis of BD is still unknown. Aberrant production of some cytokines/chemokines plays an important role in the pathogenesis of various inflammatory diseases. Revealing a key signaling regulatory mechanism involved in proinflammatory cytokines/chemokines production is critical for understanding of the pathogenesis of BD. The aim of this study was to determine the role of Src family kinases (SFKs) in production of some LPS-induced proinflammatory cytokines/chemokines in peripheral blood mononuclear cells (PBMC) of active BD patients. Chemical inhibition of SFKs activity impaired LPS-induced TNF-α production in PBMC of active BD patients, suggesting that modulating SFKs activity may be a potential target for BD treatment. |
| format | Article |
| id | doaj-art-51f5fecaaf504e0ab7e09223e1f7d9ce |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-51f5fecaaf504e0ab7e09223e1f7d9ce2025-02-03T01:31:32ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/54143695414369Pharmacological Inactivation of Src Family Kinases Inhibits LPS-Induced TNF-α Production in PBMC of Patients with Behçet’s DiseaseSevgi Irtegun0Gulsum Pektanc1Zeynep M. Akkurt2Mehtap Bozkurt3Fatih M. Turkcu4Sevgi Kalkanli-Tas5Department of Medical Biology, Faculty of Medicine, Dicle University, 21280 Diyarbakır, TurkeyDepartment of Medical Biology, Faculty of Medicine, Dicle University, 21280 Diyarbakır, TurkeyDepartment of Dermatology, Faculty of Medicine, Dicle University, 21280 Diyarbakır, TurkeyDepartment of Physical Therapy and Rehabilitation, Faculty of Medicine, Dicle University, 21280 Diyarbakır, TurkeyDepartment of Ophthalmology, Faculty of Medicine, Dicle University, 21280 Diyarbakır, TurkeyDepartment of Immunology, Faculty of Medicine, Dicle University, 21280 Diyarbakır, TurkeyBehçet’s disease (BD) is a multisystemic chronic inflammatory disease characterized by relapsing oral and genital ulcers, uveitis, and skin lesions. The pathogenesis of BD is still unknown. Aberrant production of some cytokines/chemokines plays an important role in the pathogenesis of various inflammatory diseases. Revealing a key signaling regulatory mechanism involved in proinflammatory cytokines/chemokines production is critical for understanding of the pathogenesis of BD. The aim of this study was to determine the role of Src family kinases (SFKs) in production of some LPS-induced proinflammatory cytokines/chemokines in peripheral blood mononuclear cells (PBMC) of active BD patients. Chemical inhibition of SFKs activity impaired LPS-induced TNF-α production in PBMC of active BD patients, suggesting that modulating SFKs activity may be a potential target for BD treatment.http://dx.doi.org/10.1155/2016/5414369 |
| spellingShingle | Sevgi Irtegun Gulsum Pektanc Zeynep M. Akkurt Mehtap Bozkurt Fatih M. Turkcu Sevgi Kalkanli-Tas Pharmacological Inactivation of Src Family Kinases Inhibits LPS-Induced TNF-α Production in PBMC of Patients with Behçet’s Disease Mediators of Inflammation |
| title | Pharmacological Inactivation of Src Family Kinases Inhibits LPS-Induced TNF-α Production in PBMC of Patients with Behçet’s Disease |
| title_full | Pharmacological Inactivation of Src Family Kinases Inhibits LPS-Induced TNF-α Production in PBMC of Patients with Behçet’s Disease |
| title_fullStr | Pharmacological Inactivation of Src Family Kinases Inhibits LPS-Induced TNF-α Production in PBMC of Patients with Behçet’s Disease |
| title_full_unstemmed | Pharmacological Inactivation of Src Family Kinases Inhibits LPS-Induced TNF-α Production in PBMC of Patients with Behçet’s Disease |
| title_short | Pharmacological Inactivation of Src Family Kinases Inhibits LPS-Induced TNF-α Production in PBMC of Patients with Behçet’s Disease |
| title_sort | pharmacological inactivation of src family kinases inhibits lps induced tnf α production in pbmc of patients with behcet s disease |
| url | http://dx.doi.org/10.1155/2016/5414369 |
| work_keys_str_mv | AT sevgiirtegun pharmacologicalinactivationofsrcfamilykinasesinhibitslpsinducedtnfaproductioninpbmcofpatientswithbehcetsdisease AT gulsumpektanc pharmacologicalinactivationofsrcfamilykinasesinhibitslpsinducedtnfaproductioninpbmcofpatientswithbehcetsdisease AT zeynepmakkurt pharmacologicalinactivationofsrcfamilykinasesinhibitslpsinducedtnfaproductioninpbmcofpatientswithbehcetsdisease AT mehtapbozkurt pharmacologicalinactivationofsrcfamilykinasesinhibitslpsinducedtnfaproductioninpbmcofpatientswithbehcetsdisease AT fatihmturkcu pharmacologicalinactivationofsrcfamilykinasesinhibitslpsinducedtnfaproductioninpbmcofpatientswithbehcetsdisease AT sevgikalkanlitas pharmacologicalinactivationofsrcfamilykinasesinhibitslpsinducedtnfaproductioninpbmcofpatientswithbehcetsdisease |