Unusual Clinical and Pathological Features in Pemphigus Vulgaris: A Potential Diagnostic Pitfall
We describe the case of a 67-year-old woman affected by pemphigus vulgaris with a dry whitish scaly lesion in the upper lip. Clinically, this lesion resembled an actinic keratosis. Although histological examination revealed a focal acantholysis, the finding of a moderate-to-severe dysplastic epithel...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2011/518758 |
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| author | Rosario Caltabiano Gaetano Magro Lidia Puzzo Enrico Vasquez Rocco De Pasquale |
| author_facet | Rosario Caltabiano Gaetano Magro Lidia Puzzo Enrico Vasquez Rocco De Pasquale |
| author_sort | Rosario Caltabiano |
| collection | DOAJ |
| description | We describe the case of a 67-year-old woman affected by pemphigus vulgaris with a dry whitish scaly lesion in the upper lip. Clinically, this lesion resembled an actinic keratosis. Although histological examination revealed a focal acantholysis, the finding of a moderate-to-severe dysplastic epithelium was consistent with the diagnosis of acantholytic actinic keratosis with moderate/severe dysplasia. Nevertheless, the complete resolution of the lip lesion after systemic therapy for pemphigus vulgaris led us to reconsider the possibility that we were dealing with a pemphigus vulgaris with unusual clinical and histological features. The previously reported cytological dysplasia was better regarded reactive rather than neoplastic, likely as the result to the inflammatory injury. |
| format | Article |
| id | doaj-art-51f49079578d4d87a16249de4a64dc08 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-51f49079578d4d87a16249de4a64dc082025-02-03T01:02:51ZengWileyCase Reports in Medicine1687-96271687-96352011-01-01201110.1155/2011/518758518758Unusual Clinical and Pathological Features in Pemphigus Vulgaris: A Potential Diagnostic PitfallRosario Caltabiano0Gaetano Magro1Lidia Puzzo2Enrico Vasquez3Rocco De Pasquale4Section of Anatomic Pathology, Department G.F. Ingrassia, University of Catania, 95123 Catania, ItalySection of Anatomic Pathology, Department G.F. Ingrassia, University of Catania, 95123 Catania, ItalySection of Anatomic Pathology, Department G.F. Ingrassia, University of Catania, 95123 Catania, ItalySection of Anatomic Pathology, Department G.F. Ingrassia, University of Catania, 95123 Catania, ItalyDepartment of Dermatology, University of Catania, “G. Rodolico” Polyclinic, 95123 Catania, ItalyWe describe the case of a 67-year-old woman affected by pemphigus vulgaris with a dry whitish scaly lesion in the upper lip. Clinically, this lesion resembled an actinic keratosis. Although histological examination revealed a focal acantholysis, the finding of a moderate-to-severe dysplastic epithelium was consistent with the diagnosis of acantholytic actinic keratosis with moderate/severe dysplasia. Nevertheless, the complete resolution of the lip lesion after systemic therapy for pemphigus vulgaris led us to reconsider the possibility that we were dealing with a pemphigus vulgaris with unusual clinical and histological features. The previously reported cytological dysplasia was better regarded reactive rather than neoplastic, likely as the result to the inflammatory injury.http://dx.doi.org/10.1155/2011/518758 |
| spellingShingle | Rosario Caltabiano Gaetano Magro Lidia Puzzo Enrico Vasquez Rocco De Pasquale Unusual Clinical and Pathological Features in Pemphigus Vulgaris: A Potential Diagnostic Pitfall Case Reports in Medicine |
| title | Unusual Clinical and Pathological Features in Pemphigus Vulgaris: A Potential Diagnostic Pitfall |
| title_full | Unusual Clinical and Pathological Features in Pemphigus Vulgaris: A Potential Diagnostic Pitfall |
| title_fullStr | Unusual Clinical and Pathological Features in Pemphigus Vulgaris: A Potential Diagnostic Pitfall |
| title_full_unstemmed | Unusual Clinical and Pathological Features in Pemphigus Vulgaris: A Potential Diagnostic Pitfall |
| title_short | Unusual Clinical and Pathological Features in Pemphigus Vulgaris: A Potential Diagnostic Pitfall |
| title_sort | unusual clinical and pathological features in pemphigus vulgaris a potential diagnostic pitfall |
| url | http://dx.doi.org/10.1155/2011/518758 |
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