White Blood Cell and Granulocyte Counts Are Independent Predictive Factors for Prognosis of Advanced Pancreatic Caner
Background. Pancreatic cancer is associated with high death rates and limited therapeutic options, with no effective predictive factors being available for prognosis at present. In this study, we evaluate the value of using blood test results for pancreatic cancer prognosis. Method. The records of 2...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2018/8096234 |
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| author | Lanyun Feng Shihui Gu Peng Wang Hao Chen Zhen Chen Zhiqiang Meng Luming Liu |
| author_facet | Lanyun Feng Shihui Gu Peng Wang Hao Chen Zhen Chen Zhiqiang Meng Luming Liu |
| author_sort | Lanyun Feng |
| collection | DOAJ |
| description | Background. Pancreatic cancer is associated with high death rates and limited therapeutic options, with no effective predictive factors being available for prognosis at present. In this study, we evaluate the value of using blood test results for pancreatic cancer prognosis. Method. The records of 214 pancreatic cancer patients were reviewed. Blood test results for white blood cell (WBC), granulocyte, neutrophil, lymphocyte, platelet count, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) were dichotomized on the basis of median values. This was followed by univariate and multivariate analyses between groups. Results. Patients with pretreatment values in the range WBC≥5.8×109/L, granulocyte≥3.7×109/L, neutrophil≥3.9×109/L, lymphocyte<1.4×109/L, and NLR≥2.8 showed significant correlations pointing to poorer overall survival. Multivariate analysis indicated that WBC≥5.8×109/L (HR=1.808; 95% CI=1.055–3.096; p=0.031) and granulocyte≥3.7×109/L (HR=7.346; 95% CI = 1.275–42.321; p=0.026) can be taken to be independent prognostic factors for overall survival in pancreatic patients. Conclusion. Pretreatment values of WBC and granulocyte count were independent factors with poor prognosis ability with respect to pancreatic cancer. |
| format | Article |
| id | doaj-art-51f2da1e8f2f4061a88ecd48450c412a |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-51f2da1e8f2f4061a88ecd48450c412a2025-02-03T07:25:47ZengWileyGastroenterology Research and Practice1687-61211687-630X2018-01-01201810.1155/2018/80962348096234White Blood Cell and Granulocyte Counts Are Independent Predictive Factors for Prognosis of Advanced Pancreatic CanerLanyun Feng0Shihui Gu1Peng Wang2Hao Chen3Zhen Chen4Zhiqiang Meng5Luming Liu6Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, ChinaBackground. Pancreatic cancer is associated with high death rates and limited therapeutic options, with no effective predictive factors being available for prognosis at present. In this study, we evaluate the value of using blood test results for pancreatic cancer prognosis. Method. The records of 214 pancreatic cancer patients were reviewed. Blood test results for white blood cell (WBC), granulocyte, neutrophil, lymphocyte, platelet count, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) were dichotomized on the basis of median values. This was followed by univariate and multivariate analyses between groups. Results. Patients with pretreatment values in the range WBC≥5.8×109/L, granulocyte≥3.7×109/L, neutrophil≥3.9×109/L, lymphocyte<1.4×109/L, and NLR≥2.8 showed significant correlations pointing to poorer overall survival. Multivariate analysis indicated that WBC≥5.8×109/L (HR=1.808; 95% CI=1.055–3.096; p=0.031) and granulocyte≥3.7×109/L (HR=7.346; 95% CI = 1.275–42.321; p=0.026) can be taken to be independent prognostic factors for overall survival in pancreatic patients. Conclusion. Pretreatment values of WBC and granulocyte count were independent factors with poor prognosis ability with respect to pancreatic cancer.http://dx.doi.org/10.1155/2018/8096234 |
| spellingShingle | Lanyun Feng Shihui Gu Peng Wang Hao Chen Zhen Chen Zhiqiang Meng Luming Liu White Blood Cell and Granulocyte Counts Are Independent Predictive Factors for Prognosis of Advanced Pancreatic Caner Gastroenterology Research and Practice |
| title | White Blood Cell and Granulocyte Counts Are Independent Predictive Factors for Prognosis of Advanced Pancreatic Caner |
| title_full | White Blood Cell and Granulocyte Counts Are Independent Predictive Factors for Prognosis of Advanced Pancreatic Caner |
| title_fullStr | White Blood Cell and Granulocyte Counts Are Independent Predictive Factors for Prognosis of Advanced Pancreatic Caner |
| title_full_unstemmed | White Blood Cell and Granulocyte Counts Are Independent Predictive Factors for Prognosis of Advanced Pancreatic Caner |
| title_short | White Blood Cell and Granulocyte Counts Are Independent Predictive Factors for Prognosis of Advanced Pancreatic Caner |
| title_sort | white blood cell and granulocyte counts are independent predictive factors for prognosis of advanced pancreatic caner |
| url | http://dx.doi.org/10.1155/2018/8096234 |
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