Clinical potential and experimental validation of prognostic genes in hepatocellular carcinoma revealed by risk modeling utilizing single cell and transcriptome constructs

Clinical potential and experimental validation of prognostic genes in hepatocellular carcinoma revealed by risk modeling utilizing single cell and transcriptome constructs

BackgroundHepatocellular carcinoma (HCC) is the leading cause of tumor-related mortality worldwide. There is an urgent need for predictive biomarkers to guide treatment decisions. This study aimed to identify robust prognostic genes for HCC and to establish a theoretical foundation for clinical inte...

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Bibliographic Details
Main Authors: Hang Deng, Xu Wang, Zi-Ang Jiang, Jian Xu, Yu Zhang, Yao Zhou, Jun Gong, Xiang-Yu Lu, Yi-Fu Hou, Hao Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
hepatocellular carcinoma
single-cell sequencing analysis
combination algorithms
prognostic genes
drug sensitivity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1541252/full
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