Combining single-cell and bulk RNA sequencing to identify CAF-related signature for prognostic prediction and treatment response in patients with melanoma

Combining single-cell and bulk RNA sequencing to identify CAF-related signature for prognostic prediction and treatment response in patients with melanoma

Abstract Cancer-associated fibroblasts (CAFs) play complex roles in the tumor microenvironment (TME) of melanoma. However, their impact on prognosis and treatment response in melanoma remains unclear. In this study, ScRNA-seq data (GSE115978) were utilized to characterize CAF heterogeneity and ident...

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Bibliographic Details
Main Authors: Jing Wang, Ying Song, Zifu Li, Tianxiang Gao, Wei Shen, Zijian Kang, Chong Xu
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Cancer-associated fibroblasts
Melanoma
Single-cell RNA sequencing
Prognostic biomarker
Online Access:https://doi.org/10.1038/s41598-025-14979-w
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