The Role of Toll-Like Receptors in Autoimmune Diseases through Failure of the Self-Recognition Mechanism
Toll-like receptors (TLRs), part of the innate immune system that recognises molecular signatures, are important in the recognition of pathogenic components. However, when specific cellular contexts develop in which TLRs are inappropriately activated by self-components, this may lead to sterile infl...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/8391230 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832555987615088640 |
|---|---|
| author | Mark Farrugia Byron Baron |
| author_facet | Mark Farrugia Byron Baron |
| author_sort | Mark Farrugia |
| collection | DOAJ |
| description | Toll-like receptors (TLRs), part of the innate immune system that recognises molecular signatures, are important in the recognition of pathogenic components. However, when specific cellular contexts develop in which TLRs are inappropriately activated by self-components, this may lead to sterile inflammation and result in the occurrence of autoimmunity. This review analyses the available data regarding TLR biochemistry, the specific mechanisms which are brought about by TLR activation, and the importance of these mechanisms in the light of any existing and potential therapies in the field of autoimmunity. |
| format | Article |
| id | doaj-art-51e35cf19c3c4488a2158f993d0871bd |
| institution | Kabale University |
| issn | 2090-8040 2042-0099 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-51e35cf19c3c4488a2158f993d0871bd2025-02-03T05:46:41ZengWileyInternational Journal of Inflammation2090-80402042-00992017-01-01201710.1155/2017/83912308391230The Role of Toll-Like Receptors in Autoimmune Diseases through Failure of the Self-Recognition MechanismMark Farrugia0Byron Baron1Centre for Molecular Medicine and Biobanking, Faculty of Medicine and Surgery, University of Malta, Msida MSD 2080, MaltaCentre for Molecular Medicine and Biobanking, Faculty of Medicine and Surgery, University of Malta, Msida MSD 2080, MaltaToll-like receptors (TLRs), part of the innate immune system that recognises molecular signatures, are important in the recognition of pathogenic components. However, when specific cellular contexts develop in which TLRs are inappropriately activated by self-components, this may lead to sterile inflammation and result in the occurrence of autoimmunity. This review analyses the available data regarding TLR biochemistry, the specific mechanisms which are brought about by TLR activation, and the importance of these mechanisms in the light of any existing and potential therapies in the field of autoimmunity.http://dx.doi.org/10.1155/2017/8391230 |
| spellingShingle | Mark Farrugia Byron Baron The Role of Toll-Like Receptors in Autoimmune Diseases through Failure of the Self-Recognition Mechanism International Journal of Inflammation |
| title | The Role of Toll-Like Receptors in Autoimmune Diseases through Failure of the Self-Recognition Mechanism |
| title_full | The Role of Toll-Like Receptors in Autoimmune Diseases through Failure of the Self-Recognition Mechanism |
| title_fullStr | The Role of Toll-Like Receptors in Autoimmune Diseases through Failure of the Self-Recognition Mechanism |
| title_full_unstemmed | The Role of Toll-Like Receptors in Autoimmune Diseases through Failure of the Self-Recognition Mechanism |
| title_short | The Role of Toll-Like Receptors in Autoimmune Diseases through Failure of the Self-Recognition Mechanism |
| title_sort | role of toll like receptors in autoimmune diseases through failure of the self recognition mechanism |
| url | http://dx.doi.org/10.1155/2017/8391230 |
| work_keys_str_mv | AT markfarrugia theroleoftolllikereceptorsinautoimmunediseasesthroughfailureoftheselfrecognitionmechanism AT byronbaron theroleoftolllikereceptorsinautoimmunediseasesthroughfailureoftheselfrecognitionmechanism AT markfarrugia roleoftolllikereceptorsinautoimmunediseasesthroughfailureoftheselfrecognitionmechanism AT byronbaron roleoftolllikereceptorsinautoimmunediseasesthroughfailureoftheselfrecognitionmechanism |