Window-of-opportunity trials to screen effective agents and optimize dose in breast cancer prevention

Window-of-opportunity trials to screen effective agents and optimize dose in breast cancer prevention

Abstract Window-of-opportunity trials are a path to screen effective agents and optimize dose in breast cancer risk reduction. We review the scientific evidence regarding the utility of window-of-opportunity trials to screen effective agents and optimize dose for successful risk reduction/intercepti...

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Main Authors: G. Aurilio, D. Serrano, M. Lazzeroni, A. Guerrieri-Gonzaga, H. Johansson, S. Gandini, I. M. Briata, M. D’Amico, S. Spinaci, P. Veronesi, V. Galimberti, M. Intra, B. M. Heckman-Stoddard, E. Szabo, G. Viale, B. Bonanni, A. DeCensi
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:npj Breast Cancer
Online Access:https://doi.org/10.1038/s41523-025-00745-8
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Summary:Abstract Window-of-opportunity trials are a path to screen effective agents and optimize dose in breast cancer risk reduction. We review the scientific evidence regarding the utility of window-of-opportunity trials to screen effective agents and optimize dose for successful risk reduction/interception of breast cancer. Low-dose tamoxifen was evaluated in a window-of-opportunity trial and then validated in a phase-III trial. We are now studying similar activity with low-dose exemestane.
ISSN:2374-4677

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