Human serum albumin or polyvinyl alcohol can only partially replace human plasma during in vitro red cell production from PBMC

Human serum albumin or polyvinyl alcohol can only partially replace human plasma during in vitro red cell production from PBMC

Abstract Transfusion of donor-derived red blood cells (RBC) depends on donor availability. Alloimmunization can limit the availability of transfusion units, particularly for chronically transfused patients. In vitro cultured, customizable RBC (cRBC) would negate these concerns and provide infinite R...

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Bibliographic Details
Main Authors: Marie-José A. G. Claessen, Nurcan Yagci, Gerard van Mierlo, Marie José Kersten, Marieke von Lindern, Emile van den Akker
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
cRBC—cultured red blood cells
Expansion
Differentiation
Plasma
PVA—polyvinyl alcohol
HAS—human serum albumin
Online Access:https://doi.org/10.1038/s41598-024-81341-x
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