Synthesis and Evaluation of Antimicrobial Activity of Nitrones from Derivatives of Aryl-Substituted Dihydroisoquinoline
This paper describes the synthesis of a series of dihydroisoquinoline nitrones by isomerization of the corresponding oxaziridines. Nitrones 4a–c were obtained in excellent yields and high purity by a simple and effective method from the isomerization of oxaziridines. The synthesized compounds were a...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2015/803867 |
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| author | Mouna Bouzid Raed Abdennabi Mohamed Damak Majed Kammoun |
| author_facet | Mouna Bouzid Raed Abdennabi Mohamed Damak Majed Kammoun |
| author_sort | Mouna Bouzid |
| collection | DOAJ |
| description | This paper describes the synthesis of a series of dihydroisoquinoline nitrones by isomerization of the corresponding oxaziridines. Nitrones 4a–c were obtained in excellent yields and high purity by a simple and effective method from the isomerization of oxaziridines. The synthesized compounds were also evaluated for their antibacterial activity against Gram-positive and Gram-negative bacteria and fungus. |
| format | Article |
| id | doaj-art-51c8d725c4124167ab7054e8afa5b6b7 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-51c8d725c4124167ab7054e8afa5b6b72025-02-03T05:46:05ZengWileyJournal of Chemistry2090-90632090-90712015-01-01201510.1155/2015/803867803867Synthesis and Evaluation of Antimicrobial Activity of Nitrones from Derivatives of Aryl-Substituted DihydroisoquinolineMouna Bouzid0Raed Abdennabi1Mohamed Damak2Majed Kammoun3Laboratory of Chemistry of Natural Products, Faculty of Science, Sfax University, BP 1171, 3000 Sfax, TunisiaLaboratory of Plant Biotechnology Applied to Crop Improvement, Faculty of Science, Sfax University, BP 1171, 3000 Sfax, TunisiaLaboratory of Chemistry of Natural Products, Faculty of Science, Sfax University, BP 1171, 3000 Sfax, TunisiaLaboratory of Chemistry of Natural Products, Faculty of Science, Sfax University, BP 1171, 3000 Sfax, TunisiaThis paper describes the synthesis of a series of dihydroisoquinoline nitrones by isomerization of the corresponding oxaziridines. Nitrones 4a–c were obtained in excellent yields and high purity by a simple and effective method from the isomerization of oxaziridines. The synthesized compounds were also evaluated for their antibacterial activity against Gram-positive and Gram-negative bacteria and fungus.http://dx.doi.org/10.1155/2015/803867 |
| spellingShingle | Mouna Bouzid Raed Abdennabi Mohamed Damak Majed Kammoun Synthesis and Evaluation of Antimicrobial Activity of Nitrones from Derivatives of Aryl-Substituted Dihydroisoquinoline Journal of Chemistry |
| title | Synthesis and Evaluation of Antimicrobial Activity of Nitrones from Derivatives of Aryl-Substituted Dihydroisoquinoline |
| title_full | Synthesis and Evaluation of Antimicrobial Activity of Nitrones from Derivatives of Aryl-Substituted Dihydroisoquinoline |
| title_fullStr | Synthesis and Evaluation of Antimicrobial Activity of Nitrones from Derivatives of Aryl-Substituted Dihydroisoquinoline |
| title_full_unstemmed | Synthesis and Evaluation of Antimicrobial Activity of Nitrones from Derivatives of Aryl-Substituted Dihydroisoquinoline |
| title_short | Synthesis and Evaluation of Antimicrobial Activity of Nitrones from Derivatives of Aryl-Substituted Dihydroisoquinoline |
| title_sort | synthesis and evaluation of antimicrobial activity of nitrones from derivatives of aryl substituted dihydroisoquinoline |
| url | http://dx.doi.org/10.1155/2015/803867 |
| work_keys_str_mv | AT mounabouzid synthesisandevaluationofantimicrobialactivityofnitronesfromderivativesofarylsubstituteddihydroisoquinoline AT raedabdennabi synthesisandevaluationofantimicrobialactivityofnitronesfromderivativesofarylsubstituteddihydroisoquinoline AT mohameddamak synthesisandevaluationofantimicrobialactivityofnitronesfromderivativesofarylsubstituteddihydroisoquinoline AT majedkammoun synthesisandevaluationofantimicrobialactivityofnitronesfromderivativesofarylsubstituteddihydroisoquinoline |