MATURATION OF MACROPHAGES UNDER THE INFLUENCE OF MURAMYL PEPTIDES

MATURATION OF MACROPHAGES UNDER THE INFLUENCE OF MURAMYL PEPTIDES

Abstract. Muramyl peptides from bacterial cell wall trigger the modifications in macrophages similar to maturation observed with dendritic cells. Mature macrophages reduced their capacity for phagocytosis, comparing with control, while the bactericidal activity increased. Phenotype analysis of human...

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Bibliographic Details
Main Authors: A. Il’inskaya, L. Pichugina, N. Oliferuk, V. L’vov, B. Pinegin
Format: Article
Language:Russian
Published: St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 2014-07-01
Series:Медицинская иммунология
Subjects:
macrophages
muramyl peptides
maturation
il_12, tnfα
il_6
phagocytosis
bactericidal activity
Online Access:https://www.mimmun.ru/mimmun/article/view/399
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Summary:Abstract. Muramyl peptides from bacterial cell wall trigger the modifications in macrophages similar to maturation observed with dendritic cells. Mature macrophages reduced their capacity for phagocytosis, comparing with control, while the bactericidal activity increased. Phenotype analysis of human macrophages exposed to muramyl peptides showed the increasing expression of costimulatory receptors and antigen presenting molecules. On the other hand, there was downregulation of receptors involved in recognition and engulfing of microorganism. In response to bacterial component macrophages secreted several cytokines: IL–12, TNFα, IL–6. (Med. Immunol., 2005, vol.7, № 1, pp. 21526)
ISSN:1563-0625
2313-741X

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