Morin hydrate protects against cisplatin-induced testicular toxicity by modulating ferroptosis and steroidogenesis genes’ expression and upregulating Nrf2/Heme oxygenase-1
Abstract Cisplatin is a widely used, effective chemotherapy drug. However, its application is often limited by severe side effects, including testicular toxicity. Cisplatin-induced testicular damage is primarily driven by oxidative stress and inflammation. Ferroptosis has recently been identified to...
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| Main Authors: | Yasmin Mahran, Amira M. Badr, Sheka Aloyouni, Manal Mubarak Alkahtani, Wedad S. Sarawi, Rehab Ali, Deema Alsultan, Sarah Almufadhili, Dalia H. Almasud, Iman H. Hasan |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-08235-4 |
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