Morin hydrate protects against cisplatin-induced testicular toxicity by modulating ferroptosis and steroidogenesis genes’ expression and upregulating Nrf2/Heme oxygenase-1

Morin hydrate protects against cisplatin-induced testicular toxicity by modulating ferroptosis and steroidogenesis genes’ expression and upregulating Nrf2/Heme oxygenase-1

Abstract Cisplatin is a widely used, effective chemotherapy drug. However, its application is often limited by severe side effects, including testicular toxicity. Cisplatin-induced testicular damage is primarily driven by oxidative stress and inflammation. Ferroptosis has recently been identified to...

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Main Authors: Yasmin Mahran, Amira M. Badr, Sheka Aloyouni, Manal Mubarak Alkahtani, Wedad S. Sarawi, Rehab Ali, Deema Alsultan, Sarah Almufadhili, Dalia H. Almasud, Iman H. Hasan
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Cisplatin
Morin hydrate
Ferroptosis
Oxidative stress
Testicular toxicity
Steroidogenesis
Online Access:https://doi.org/10.1038/s41598-025-08235-4
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https://doi.org/10.1038/s41598-025-08235-4

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