Comparative Effects of Umbilical Cord- and Menstrual Blood-Derived MSCs in Repairing Acute Lung Injury
Mesenchymal stem cells (MSCs) can effectively relieve acute lung injury (ALI) in several in vivo models. However, the underlying mechanisms and optimal sources of MSCs are unclear. In the present study, we investigated the effects of umbilical cord- (UC-) and menstrual blood- (MB-) derived MSCs on A...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2018/7873625 |
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| author | Haitao Ren Qiang Zhang Jinfu Wang Ruolang Pan |
| author_facet | Haitao Ren Qiang Zhang Jinfu Wang Ruolang Pan |
| author_sort | Haitao Ren |
| collection | DOAJ |
| description | Mesenchymal stem cells (MSCs) can effectively relieve acute lung injury (ALI) in several in vivo models. However, the underlying mechanisms and optimal sources of MSCs are unclear. In the present study, we investigated the effects of umbilical cord- (UC-) and menstrual blood- (MB-) derived MSCs on ALI. MSCs were transplanted into a lipopolysaccharide-induced ALI mouse model, and the therapeutic effects were determined by histological, cellular, and biochemical analyses. Our results showed that both UCMSC and MBMSC transplantation inhibited the inflammatory response and promoted lung tissue repair. UCMSC treatment resulted in reduced damage and inflammation in the lung tissue and enhanced protection of lung function. Furthermore, we found that UCMSCs secreted higher levels of anti-inflammatory cytokines (interleukin-10 and keratinocyte growth factor) in ALI-related conditions, which may be due to the greater therapeutic capacity of UCMSCs compared with MBMSCs. These findings suggest that MSCs protected the lipopolysaccharide-induced ALI model by regulating inflammation, most likely via paracrine factors. Moreover, MSCs derived from the UC may be a promising alternative for ALI treatment. |
| format | Article |
| id | doaj-art-51ae90cedd8b471e948103ebbda2c7da |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-51ae90cedd8b471e948103ebbda2c7da2025-02-03T01:10:55ZengWileyStem Cells International1687-966X1687-96782018-01-01201810.1155/2018/78736257873625Comparative Effects of Umbilical Cord- and Menstrual Blood-Derived MSCs in Repairing Acute Lung InjuryHaitao Ren0Qiang Zhang1Jinfu Wang2Ruolang Pan3Department of Burns and Wound Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, ChinaKey Laboratory of Cell-Based Drug and Applied Technology Development in Zhejiang Province, Hangzhou 311121, ChinaInstitute of Cell and Development, College of Life Science, Zhejiang University, Hangzhou 310058, ChinaKey Laboratory of Cell-Based Drug and Applied Technology Development in Zhejiang Province, Hangzhou 311121, ChinaMesenchymal stem cells (MSCs) can effectively relieve acute lung injury (ALI) in several in vivo models. However, the underlying mechanisms and optimal sources of MSCs are unclear. In the present study, we investigated the effects of umbilical cord- (UC-) and menstrual blood- (MB-) derived MSCs on ALI. MSCs were transplanted into a lipopolysaccharide-induced ALI mouse model, and the therapeutic effects were determined by histological, cellular, and biochemical analyses. Our results showed that both UCMSC and MBMSC transplantation inhibited the inflammatory response and promoted lung tissue repair. UCMSC treatment resulted in reduced damage and inflammation in the lung tissue and enhanced protection of lung function. Furthermore, we found that UCMSCs secreted higher levels of anti-inflammatory cytokines (interleukin-10 and keratinocyte growth factor) in ALI-related conditions, which may be due to the greater therapeutic capacity of UCMSCs compared with MBMSCs. These findings suggest that MSCs protected the lipopolysaccharide-induced ALI model by regulating inflammation, most likely via paracrine factors. Moreover, MSCs derived from the UC may be a promising alternative for ALI treatment.http://dx.doi.org/10.1155/2018/7873625 |
| spellingShingle | Haitao Ren Qiang Zhang Jinfu Wang Ruolang Pan Comparative Effects of Umbilical Cord- and Menstrual Blood-Derived MSCs in Repairing Acute Lung Injury Stem Cells International |
| title | Comparative Effects of Umbilical Cord- and Menstrual Blood-Derived MSCs in Repairing Acute Lung Injury |
| title_full | Comparative Effects of Umbilical Cord- and Menstrual Blood-Derived MSCs in Repairing Acute Lung Injury |
| title_fullStr | Comparative Effects of Umbilical Cord- and Menstrual Blood-Derived MSCs in Repairing Acute Lung Injury |
| title_full_unstemmed | Comparative Effects of Umbilical Cord- and Menstrual Blood-Derived MSCs in Repairing Acute Lung Injury |
| title_short | Comparative Effects of Umbilical Cord- and Menstrual Blood-Derived MSCs in Repairing Acute Lung Injury |
| title_sort | comparative effects of umbilical cord and menstrual blood derived mscs in repairing acute lung injury |
| url | http://dx.doi.org/10.1155/2018/7873625 |
| work_keys_str_mv | AT haitaoren comparativeeffectsofumbilicalcordandmenstrualbloodderivedmscsinrepairingacutelunginjury AT qiangzhang comparativeeffectsofumbilicalcordandmenstrualbloodderivedmscsinrepairingacutelunginjury AT jinfuwang comparativeeffectsofumbilicalcordandmenstrualbloodderivedmscsinrepairingacutelunginjury AT ruolangpan comparativeeffectsofumbilicalcordandmenstrualbloodderivedmscsinrepairingacutelunginjury |