Chemical circularization of in vitro transcribed RNA for exploring circular mRNA design

Chemical circularization of in vitro transcribed RNA for exploring circular mRNA design

Abstract Circularization is an important step for therapeutic messenger RNA (mRNA) enhancements. Current enzymatic and ribozymatic-based circularization methods face limitations including sequence constraints, purification challenges, and sub-optimal biological activity. Chemical strategies, while p...

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Main Authors: Malgorzata Wasinska-Kalwa, Adam Mamot, Karol Czubak, Katarzyna Frankowska, Adam Ado Rajkiewicz, Tomasz Spiewla, Marcin Warminski, Zofia Pilch, Marta Szulc-Gasiorowska, Kacper Siekan, Andrzej Dziembowski, Dominika Nowis, Jakub Golab, Joanna Kowalska, Jacek Jemielity
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61775-1
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