The extra-islet pancreas supports autoimmunity in human type 1 diabetes

The extra-islet pancreas supports autoimmunity in human type 1 diabetes

In autoimmune type 1 diabetes (T1D), immune cells infiltrate and destroy the islets of Langerhans — islands of endocrine tissue dispersed throughout the pancreas. However, the contribution of cellular programs outside islets to insulitis is unclear. Here, using CO-Detection by indEXing (CODEX) tissu...

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Main Authors: Graham L Barlow, Christian M Schürch, Salil S Bhate, Darci J Phillips, Arabella Young, Shen Dong, Hunter A Martinez, Gernot Kaber, Nadine Nagy, Sasvath Ramachandran, Janet Meng, Eva Korpos, Jeffrey A Bluestone, Garry P Nolan, Paul L Bollyky
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-04-01
Series:eLife
Subjects:
immunology
autoimmunity
type 1 diabetes
Online Access:https://elifesciences.org/articles/100535
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https://elifesciences.org/articles/100535

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