Beneficial effects of the fructus Sophorae extract on experimentally induced osteoporosis in New Zealand white rabbits
Sophora japonica is a source of several flavonol, flavone and isoflavone glycosides that are reported to positively affect menopausal symptoms including osteoporotic complications. In the present study fructus Sophorae extract (FSE) was administered orally for three months at a dose of 200 mg kg–1 i...
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2022-06-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2022-0012 |
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| author | CHAKULESKA LIDIJA SHKONDROV ALEKSANDAR POPOV GEORGI ZLATEVA-PANAYOTOVA NADYA PETROVA RENETA ATANASOVA MARIYANA KRASTEVA ILINA DOYTCHINOVA IRINI SIMEONOVA RUMYANA |
| author_facet | CHAKULESKA LIDIJA SHKONDROV ALEKSANDAR POPOV GEORGI ZLATEVA-PANAYOTOVA NADYA PETROVA RENETA ATANASOVA MARIYANA KRASTEVA ILINA DOYTCHINOVA IRINI SIMEONOVA RUMYANA |
| author_sort | CHAKULESKA LIDIJA |
| collection | DOAJ |
| description | Sophora japonica is a source of several flavonol, flavone and isoflavone glycosides that are reported to positively affect menopausal symptoms including osteoporotic complications. In the present study fructus Sophorae extract (FSE) was administered orally for three months at a dose of 200 mg kg–1 in ovariectomized (OVX) New Zealand rabbits. 3D computed tomography scans and histopathological images revealed microstructural disturbances in the bones of the castrated animals. FSE recovered most of the affected parameters in bones in a manner similar to zoledronic acid (ZA) used as a positive control. The aglycones of the main active compounds of FSE, daidzin, and genistin, were docked into the alpha and beta estrogen receptors and stable complexes were found. The findings of this study provide an insight into the effects of FSE on bone tissue loss and suggest that it could be further developed as a potential candidate for the prevention of postmenopausal osteoporotic complications. |
| format | Article |
| id | doaj-art-5143aa01c0594f0bb392ff991d4c9f69 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-5143aa01c0594f0bb392ff991d4c9f692025-02-02T02:10:55ZengSciendoActa Pharmaceutica1846-95582022-06-0172228930210.2478/acph-2022-0012Beneficial effects of the fructus Sophorae extract on experimentally induced osteoporosis in New Zealand white rabbitsCHAKULESKA LIDIJA0SHKONDROV ALEKSANDAR1POPOV GEORGI2ZLATEVA-PANAYOTOVA NADYA3PETROVA RENETA4ATANASOVA MARIYANA5KRASTEVA ILINA6DOYTCHINOVA IRINI7SIMEONOVA RUMYANA81Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, 1000Sofia, Bulgaria2Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Sofia, 1000Sofia, Bulgaria3Department of Internal Non-infectious Diseases Pathology and Pharmacology, Faculty of Veterinary Medicine, University of Forestry 101756Sofia, Bulgaria4Department of Surgery and Radiology, Faculty of Veterinary Medicine, University of Forestry, 101756Sofia, Bulgaria5National Diagnostic and Research Veterinary Institute, Department: National Center of Animal Health, Sofia, Bulgaria6Department of Chemistry, Faculty of PharmacyMedical University of Sofia, 1000Sofia, Bulgaria2Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Sofia, 1000Sofia, Bulgaria6Department of Chemistry, Faculty of PharmacyMedical University of Sofia, 1000Sofia, Bulgaria1Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, 1000Sofia, BulgariaSophora japonica is a source of several flavonol, flavone and isoflavone glycosides that are reported to positively affect menopausal symptoms including osteoporotic complications. In the present study fructus Sophorae extract (FSE) was administered orally for three months at a dose of 200 mg kg–1 in ovariectomized (OVX) New Zealand rabbits. 3D computed tomography scans and histopathological images revealed microstructural disturbances in the bones of the castrated animals. FSE recovered most of the affected parameters in bones in a manner similar to zoledronic acid (ZA) used as a positive control. The aglycones of the main active compounds of FSE, daidzin, and genistin, were docked into the alpha and beta estrogen receptors and stable complexes were found. The findings of this study provide an insight into the effects of FSE on bone tissue loss and suggest that it could be further developed as a potential candidate for the prevention of postmenopausal osteoporotic complications.https://doi.org/10.2478/acph-2022-0012osteoporosissophora japonica fruitsovariectomized rabbitsmolecular dockingestrogen receptors |
| spellingShingle | CHAKULESKA LIDIJA SHKONDROV ALEKSANDAR POPOV GEORGI ZLATEVA-PANAYOTOVA NADYA PETROVA RENETA ATANASOVA MARIYANA KRASTEVA ILINA DOYTCHINOVA IRINI SIMEONOVA RUMYANA Beneficial effects of the fructus Sophorae extract on experimentally induced osteoporosis in New Zealand white rabbits Acta Pharmaceutica osteoporosis sophora japonica fruits ovariectomized rabbits molecular docking estrogen receptors |
| title | Beneficial effects of the fructus Sophorae extract on experimentally induced osteoporosis in New Zealand white rabbits |
| title_full | Beneficial effects of the fructus Sophorae extract on experimentally induced osteoporosis in New Zealand white rabbits |
| title_fullStr | Beneficial effects of the fructus Sophorae extract on experimentally induced osteoporosis in New Zealand white rabbits |
| title_full_unstemmed | Beneficial effects of the fructus Sophorae extract on experimentally induced osteoporosis in New Zealand white rabbits |
| title_short | Beneficial effects of the fructus Sophorae extract on experimentally induced osteoporosis in New Zealand white rabbits |
| title_sort | beneficial effects of the fructus sophorae extract on experimentally induced osteoporosis in new zealand white rabbits |
| topic | osteoporosis sophora japonica fruits ovariectomized rabbits molecular docking estrogen receptors |
| url | https://doi.org/10.2478/acph-2022-0012 |
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