Evaluation of the microenvironment formed by interferon-β
Heterogeneity in the cellular microenvironment in vivo affects the variability of reactivity among immune cells. Individual-specific microenvironmental differences play a crucial role in determining macroscopic outcomes, such as the efficacy of immunotherapy and disease progression. The microenviron...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Chemical Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fchbi.2024.1425571/full |
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| author | Mai Yamagishi Mai Yamagishi Yutaka Hori Nobutake Suzuki Nobutake Suzuki Yu Peng Yu Peng Yoshie Harada Takashi Funatsu Osamu Ohara Yoshitaka Shirasaki Yoshitaka Shirasaki |
| author_facet | Mai Yamagishi Mai Yamagishi Yutaka Hori Nobutake Suzuki Nobutake Suzuki Yu Peng Yu Peng Yoshie Harada Takashi Funatsu Osamu Ohara Yoshitaka Shirasaki Yoshitaka Shirasaki |
| author_sort | Mai Yamagishi |
| collection | DOAJ |
| description | Heterogeneity in the cellular microenvironment in vivo affects the variability of reactivity among immune cells. Individual-specific microenvironmental differences play a crucial role in determining macroscopic outcomes, such as the efficacy of immunotherapy and disease progression. The microenvironment is also featured by cytokines released from cells, significantly regulating immune cell function. However, the overall understanding, at single-cell resolution, of how cytokines shape the microenvironment and promote paracrine signaling remains unclear. In this manuscript, we propose a methodology that addresses both the microenvironment itself and the response to the microenvironment to comprehend microenvironment behavior at the single-cell level. Our objective is to contribute to the basic understanding of the interplay between immune cells and their microenvironment, with particular relevance to implications for immunotherapy and disease progression. |
| format | Article |
| id | doaj-art-513f56e0eb5a452a97fa17ce6d71d175 |
| institution | Kabale University |
| issn | 2813-530X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemical Biology |
| spelling | doaj-art-513f56e0eb5a452a97fa17ce6d71d1752025-01-21T08:36:51ZengFrontiers Media S.A.Frontiers in Chemical Biology2813-530X2025-01-01310.3389/fchbi.2024.14255711425571Evaluation of the microenvironment formed by interferon-βMai Yamagishi0Mai Yamagishi1Yutaka Hori2Nobutake Suzuki3Nobutake Suzuki4Yu Peng5Yu Peng6Yoshie Harada7Takashi Funatsu8Osamu Ohara9Yoshitaka Shirasaki10Yoshitaka Shirasaki11Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, JapanLive Cell Diagnosis, Ltd., Saitama, JapanDepartment of Applied Physics and Physico-informatics, Faculty of Science and Technology, Keio University, Yokohama, Kanagawa, JapanGraduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, JapanLive Cell Diagnosis, Ltd., Saitama, JapanInstitute for Protein Research, Osaka University, Osaka, JapanGraduate School of Science, Osaka University, Osaka, JapanInstitute for Protein Research, Osaka University, Osaka, JapanGraduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, JapanDepartment of Applied Genomics, Kazusa DNA Research Institute, Chiba, JapanGraduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, JapanResearch Center for Advanced Science and Technology, The University of Tokyo, Tokyo, JapanHeterogeneity in the cellular microenvironment in vivo affects the variability of reactivity among immune cells. Individual-specific microenvironmental differences play a crucial role in determining macroscopic outcomes, such as the efficacy of immunotherapy and disease progression. The microenvironment is also featured by cytokines released from cells, significantly regulating immune cell function. However, the overall understanding, at single-cell resolution, of how cytokines shape the microenvironment and promote paracrine signaling remains unclear. In this manuscript, we propose a methodology that addresses both the microenvironment itself and the response to the microenvironment to comprehend microenvironment behavior at the single-cell level. Our objective is to contribute to the basic understanding of the interplay between immune cells and their microenvironment, with particular relevance to implications for immunotherapy and disease progression.https://www.frontiersin.org/articles/10.3389/fchbi.2024.1425571/fullcytokinemicroenvironmentlive-cell imagingheterogeneityimmune responseIFN-β |
| spellingShingle | Mai Yamagishi Mai Yamagishi Yutaka Hori Nobutake Suzuki Nobutake Suzuki Yu Peng Yu Peng Yoshie Harada Takashi Funatsu Osamu Ohara Yoshitaka Shirasaki Yoshitaka Shirasaki Evaluation of the microenvironment formed by interferon-β Frontiers in Chemical Biology cytokine microenvironment live-cell imaging heterogeneity immune response IFN-β |
| title | Evaluation of the microenvironment formed by interferon-β |
| title_full | Evaluation of the microenvironment formed by interferon-β |
| title_fullStr | Evaluation of the microenvironment formed by interferon-β |
| title_full_unstemmed | Evaluation of the microenvironment formed by interferon-β |
| title_short | Evaluation of the microenvironment formed by interferon-β |
| title_sort | evaluation of the microenvironment formed by interferon β |
| topic | cytokine microenvironment live-cell imaging heterogeneity immune response IFN-β |
| url | https://www.frontiersin.org/articles/10.3389/fchbi.2024.1425571/full |
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