The Impact of Antidepressants on Gut Microbiome and Depression Management
Depression is a widespread psychiatric disorder that significantly impacts an individual’s quality of life. It affects mental and emotional well-being and has far-reaching consequences on their physical health, relationships, and overall ability to function in daily life. Recent advances in psychia...
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| Format: | Article |
| Language: | English |
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HH Publisher
2024-07-01
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| Series: | Progress in Microbes and Molecular Biology |
| Online Access: | https://journals.hh-publisher.com/index.php/pmmb/article/view/1040 |
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| author | Ee-Kit Tang Ke-Yan Loo Angel Yun-Kuan Thye Jodi Woan-Fei Law Loh Teng-Hern Tan Malarvili Selvaraja Sivakumar Thurairajasingam Learn-Han Lee Vengadesh Letchumanan |
| author_facet | Ee-Kit Tang Ke-Yan Loo Angel Yun-Kuan Thye Jodi Woan-Fei Law Loh Teng-Hern Tan Malarvili Selvaraja Sivakumar Thurairajasingam Learn-Han Lee Vengadesh Letchumanan |
| author_sort | Ee-Kit Tang |
| collection | DOAJ |
| description |
Depression is a widespread psychiatric disorder that significantly impacts an individual’s quality of life. It affects mental and emotional well-being and has far-reaching consequences on their physical health, relationships, and overall ability to function in daily life. Recent advances in psychiatric research have revealed a connection between the gut-brain axis, a bidirectional communication system linking the brain's emotional and cognitive centers with intestinal functions. Antidepressants, including selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs), and monoamine oxidase inhibitors (MAOIs), are commonly prescribed to alleviate symptoms of depression. However, their influence extends beyond neurotransmitter modulation in the brain to significant effects on gastrointestinal physiology. Antidepressants can alter gut motility, secretion, and microbiota composition, which in turn can influence mood and mental health. This review aims to provide insights into the impact of antidepressants on gut health and their implications for depression treatment. Additionally, it explores the potential of probiotics as an adjunct treatment to enhance the efficacy of antidepressants and mitigate gastrointestinal side effects. Restoring healthy gut microbiota can improve gastrointestinal and mental health outcomes, suggesting a promising avenue for integrated therapeutic approaches.
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| format | Article |
| id | doaj-art-512595d7a01747a9abec35ba5f749eac |
| institution | Kabale University |
| issn | 2637-1049 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | HH Publisher |
| record_format | Article |
| series | Progress in Microbes and Molecular Biology |
| spelling | doaj-art-512595d7a01747a9abec35ba5f749eac2025-02-04T08:39:37ZengHH PublisherProgress in Microbes and Molecular Biology2637-10492024-07-017110.36877/pmmb.a0000446The Impact of Antidepressants on Gut Microbiome and Depression ManagementEe-Kit TangKe-Yan LooAngel Yun-Kuan ThyeJodi Woan-Fei LawLoh Teng-Hern TanMalarvili SelvarajaSivakumar ThurairajasingamLearn-Han LeeVengadesh Letchumanan Depression is a widespread psychiatric disorder that significantly impacts an individual’s quality of life. It affects mental and emotional well-being and has far-reaching consequences on their physical health, relationships, and overall ability to function in daily life. Recent advances in psychiatric research have revealed a connection between the gut-brain axis, a bidirectional communication system linking the brain's emotional and cognitive centers with intestinal functions. Antidepressants, including selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs), and monoamine oxidase inhibitors (MAOIs), are commonly prescribed to alleviate symptoms of depression. However, their influence extends beyond neurotransmitter modulation in the brain to significant effects on gastrointestinal physiology. Antidepressants can alter gut motility, secretion, and microbiota composition, which in turn can influence mood and mental health. This review aims to provide insights into the impact of antidepressants on gut health and their implications for depression treatment. Additionally, it explores the potential of probiotics as an adjunct treatment to enhance the efficacy of antidepressants and mitigate gastrointestinal side effects. Restoring healthy gut microbiota can improve gastrointestinal and mental health outcomes, suggesting a promising avenue for integrated therapeutic approaches. https://journals.hh-publisher.com/index.php/pmmb/article/view/1040 |
| spellingShingle | Ee-Kit Tang Ke-Yan Loo Angel Yun-Kuan Thye Jodi Woan-Fei Law Loh Teng-Hern Tan Malarvili Selvaraja Sivakumar Thurairajasingam Learn-Han Lee Vengadesh Letchumanan The Impact of Antidepressants on Gut Microbiome and Depression Management Progress in Microbes and Molecular Biology |
| title | The Impact of Antidepressants on Gut Microbiome and Depression Management |
| title_full | The Impact of Antidepressants on Gut Microbiome and Depression Management |
| title_fullStr | The Impact of Antidepressants on Gut Microbiome and Depression Management |
| title_full_unstemmed | The Impact of Antidepressants on Gut Microbiome and Depression Management |
| title_short | The Impact of Antidepressants on Gut Microbiome and Depression Management |
| title_sort | impact of antidepressants on gut microbiome and depression management |
| url | https://journals.hh-publisher.com/index.php/pmmb/article/view/1040 |
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