From pathogenesis to new developments in treatment of primary progressive multiple sclerosis. Literature review
Multiple sclerosis (MS) is characterised as a chronic autoimmune inflammatory disease of the central nervous system (CNS) affecting more than 2.3 million people all over the world. Approximately 15% of all MS cases are manifesting as primary progressive MS (PPMS). Inflammation has long been thought...
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| Format: | Article |
| Language: | English |
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Vilnius University Press
2020-03-01
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| Series: | Neurologijos seminarai |
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| Online Access: | https://www.journals.vu.lt/neurologijos_seminarai/article/view/27759 |
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| author | A. Juknelytė Ž. Vaičekauskytė D. Mickevičienė R. Balnytė |
| author_facet | A. Juknelytė Ž. Vaičekauskytė D. Mickevičienė R. Balnytė |
| author_sort | A. Juknelytė |
| collection | DOAJ |
| description |
Multiple sclerosis (MS) is characterised as a chronic autoimmune inflammatory disease of the central nervous system (CNS) affecting more than 2.3 million people all over the world. Approximately 15% of all MS cases are manifesting as primary progressive MS (PPMS). Inflammation has long been thought to be the initial factor that starts pathological mechanisms, and neurodegeneration only enhances the progression of the disease. Recent data reveal more precise details about the pathogenesis of PPMS that led to the development of a new drug. After years of failed treatment methods, the new drug Ocrelizumab has shown promising results in the treatment of PPMS. The drug was approved in 2018 by the European Medicines Agency (EMA). Considered an incurable disease, PPMS today gives patients more hope of stopping the progression of disability.
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| format | Article |
| id | doaj-art-511c967fec614cc787dd3f6cdebe844b |
| institution | Kabale University |
| issn | 1392-3064 2424-5917 |
| language | English |
| publishDate | 2020-03-01 |
| publisher | Vilnius University Press |
| record_format | Article |
| series | Neurologijos seminarai |
| spelling | doaj-art-511c967fec614cc787dd3f6cdebe844b2025-01-20T18:22:50ZengVilnius University PressNeurologijos seminarai1392-30642424-59172020-03-01241(83)10.29014/ns.2020.04From pathogenesis to new developments in treatment of primary progressive multiple sclerosis. Literature reviewA. Juknelytė 0Ž. Vaičekauskytė 1D. Mickevičienė 2R. Balnytė 3Lithuanian University of Health SciencesLithuanian University of Health SciencesLithuanian University of Health SciencesLithuanian University of Health Sciences Multiple sclerosis (MS) is characterised as a chronic autoimmune inflammatory disease of the central nervous system (CNS) affecting more than 2.3 million people all over the world. Approximately 15% of all MS cases are manifesting as primary progressive MS (PPMS). Inflammation has long been thought to be the initial factor that starts pathological mechanisms, and neurodegeneration only enhances the progression of the disease. Recent data reveal more precise details about the pathogenesis of PPMS that led to the development of a new drug. After years of failed treatment methods, the new drug Ocrelizumab has shown promising results in the treatment of PPMS. The drug was approved in 2018 by the European Medicines Agency (EMA). Considered an incurable disease, PPMS today gives patients more hope of stopping the progression of disability. https://www.journals.vu.lt/neurologijos_seminarai/article/view/27759primary progressive multiple sclerosisocrelizumabdisease modifying drugpathogenesis |
| spellingShingle | A. Juknelytė Ž. Vaičekauskytė D. Mickevičienė R. Balnytė From pathogenesis to new developments in treatment of primary progressive multiple sclerosis. Literature review Neurologijos seminarai primary progressive multiple sclerosis ocrelizumab disease modifying drug pathogenesis |
| title | From pathogenesis to new developments in treatment of primary progressive multiple sclerosis. Literature review |
| title_full | From pathogenesis to new developments in treatment of primary progressive multiple sclerosis. Literature review |
| title_fullStr | From pathogenesis to new developments in treatment of primary progressive multiple sclerosis. Literature review |
| title_full_unstemmed | From pathogenesis to new developments in treatment of primary progressive multiple sclerosis. Literature review |
| title_short | From pathogenesis to new developments in treatment of primary progressive multiple sclerosis. Literature review |
| title_sort | from pathogenesis to new developments in treatment of primary progressive multiple sclerosis literature review |
| topic | primary progressive multiple sclerosis ocrelizumab disease modifying drug pathogenesis |
| url | https://www.journals.vu.lt/neurologijos_seminarai/article/view/27759 |
| work_keys_str_mv | AT ajuknelyte frompathogenesistonewdevelopmentsintreatmentofprimaryprogressivemultiplesclerosisliteraturereview AT zvaicekauskyte frompathogenesistonewdevelopmentsintreatmentofprimaryprogressivemultiplesclerosisliteraturereview AT dmickeviciene frompathogenesistonewdevelopmentsintreatmentofprimaryprogressivemultiplesclerosisliteraturereview AT rbalnyte frompathogenesistonewdevelopmentsintreatmentofprimaryprogressivemultiplesclerosisliteraturereview |