Developing anti-TDE vaccine for sensitizing cancer cells to treatment and metastasis control
Abstract Tumor-derived exosomes (TDEs) mediate oncogenic communication, which modifies target cells to reinforce a tumor-promoting microenvironment. TDEs support cancer progression by suppressing anti-tumor immune responses, promoting metastasis, and conferring drug resistance. Thus, targeting TDEs...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | npj Vaccines |
| Online Access: | https://doi.org/10.1038/s41541-024-01035-3 |
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| author | Stephene S. Meena Benson K. Kosgei Geofrey F. Soko Cheng Tingjun Ramadhani Chambuso Julius Mwaiselage Ray P. S. Han |
| author_facet | Stephene S. Meena Benson K. Kosgei Geofrey F. Soko Cheng Tingjun Ramadhani Chambuso Julius Mwaiselage Ray P. S. Han |
| author_sort | Stephene S. Meena |
| collection | DOAJ |
| description | Abstract Tumor-derived exosomes (TDEs) mediate oncogenic communication, which modifies target cells to reinforce a tumor-promoting microenvironment. TDEs support cancer progression by suppressing anti-tumor immune responses, promoting metastasis, and conferring drug resistance. Thus, targeting TDEs could improve the efficacy of anti-cancer treatments and control metastasis. Current strategies to inhibit TDE-mediated oncogenic communication including drug-based and genetic modification-based inhibition of TDE release and/or uptake, have proved to be inefficient. In this work, we propose TDE surface engineering to express foreign antigens that will trigger life-long anti-TDE immune responses. The possibility of combining the anti-TDE vaccines with other treatments such as chemotherapy, radiotherapy, targeted therapy, and surgery is also explored. |
| format | Article |
| id | doaj-art-511933b12db04e368f4b7e1da02e6dc0 |
| institution | Kabale University |
| issn | 2059-0105 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Vaccines |
| spelling | doaj-art-511933b12db04e368f4b7e1da02e6dc02025-02-02T12:07:34ZengNature Portfolionpj Vaccines2059-01052025-01-0110111510.1038/s41541-024-01035-3Developing anti-TDE vaccine for sensitizing cancer cells to treatment and metastasis controlStephene S. Meena0Benson K. Kosgei1Geofrey F. Soko2Cheng Tingjun3Ramadhani Chambuso4Julius Mwaiselage5Ray P. S. Han6Jiangzhong Cancer Research Center, Jiangxi University of Chinese MedicineJiangzhong Cancer Research Center, Jiangxi University of Chinese MedicineJiangzhong Cancer Research Center, Jiangxi University of Chinese MedicineJiangzhong Cancer Research Center, Jiangxi University of Chinese MedicineDepartment of Global Health and Population, Harvard Chan School of Public Health, Harvard UniversityOcean Road Cancer InstituteJiangzhong Cancer Research Center, Jiangxi University of Chinese MedicineAbstract Tumor-derived exosomes (TDEs) mediate oncogenic communication, which modifies target cells to reinforce a tumor-promoting microenvironment. TDEs support cancer progression by suppressing anti-tumor immune responses, promoting metastasis, and conferring drug resistance. Thus, targeting TDEs could improve the efficacy of anti-cancer treatments and control metastasis. Current strategies to inhibit TDE-mediated oncogenic communication including drug-based and genetic modification-based inhibition of TDE release and/or uptake, have proved to be inefficient. In this work, we propose TDE surface engineering to express foreign antigens that will trigger life-long anti-TDE immune responses. The possibility of combining the anti-TDE vaccines with other treatments such as chemotherapy, radiotherapy, targeted therapy, and surgery is also explored.https://doi.org/10.1038/s41541-024-01035-3 |
| spellingShingle | Stephene S. Meena Benson K. Kosgei Geofrey F. Soko Cheng Tingjun Ramadhani Chambuso Julius Mwaiselage Ray P. S. Han Developing anti-TDE vaccine for sensitizing cancer cells to treatment and metastasis control npj Vaccines |
| title | Developing anti-TDE vaccine for sensitizing cancer cells to treatment and metastasis control |
| title_full | Developing anti-TDE vaccine for sensitizing cancer cells to treatment and metastasis control |
| title_fullStr | Developing anti-TDE vaccine for sensitizing cancer cells to treatment and metastasis control |
| title_full_unstemmed | Developing anti-TDE vaccine for sensitizing cancer cells to treatment and metastasis control |
| title_short | Developing anti-TDE vaccine for sensitizing cancer cells to treatment and metastasis control |
| title_sort | developing anti tde vaccine for sensitizing cancer cells to treatment and metastasis control |
| url | https://doi.org/10.1038/s41541-024-01035-3 |
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