Polystyrene nanoplastics promote the blood-brain barrier dysfunction through autophagy pathway and excessive erythrophagocytosis
There is increasing concern regarding the risks posed by plastics to human health. Nano-sized plastics enter the body through various exposure routes. Although nano-sized particles circulate through the bloodstream and access the blood-brain barrier (BBB), the harmful impacts of nano-sized plastics...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324015471 |
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| author | Eun-Hye Kim Seung Mi Baek Han Jin Park Yiying Bian Han Young Chung Ok-Nam Bae |
| author_facet | Eun-Hye Kim Seung Mi Baek Han Jin Park Yiying Bian Han Young Chung Ok-Nam Bae |
| author_sort | Eun-Hye Kim |
| collection | DOAJ |
| description | There is increasing concern regarding the risks posed by plastics to human health. Nano-sized plastics enter the body through various exposure routes. Although nano-sized particles circulate through the bloodstream and access the blood-brain barrier (BBB), the harmful impacts of nano-sized plastics on BBB function including endothelial cells are not well known. In this study, polystyrene nanoplastics (PS-NP) resulted in hyperpermeability and damaged tight junction proteins in brain endothelial cells. We identified that PS-NP increased intracellular iron levels by inhibiting the autophagy pathway in brain endothelial cells. Our study showed that dysregulated autophagy pathways led to increased BBB permeability induced by PS-NP treatment. In addition, PS-NP caused excessive erythrophagocytosis in brain endothelial cells via damaged red blood cells. PS-NP-treated RBCs (NP-RBC) induced the BBB dysfunction and increased intracellular iron levels and ferroptosis in brain endothelial cells. We provide novel insights into the potential risks of nano-sized plastics in BBB function by interaction between cells as well as direct exposure. Our study will help to understand the cardiovascular toxicity of nano-sized plastics. |
| format | Article |
| id | doaj-art-51137c602e9745adb7cb90a3358109b4 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-51137c602e9745adb7cb90a3358109b42025-01-23T05:25:41ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01289117471Polystyrene nanoplastics promote the blood-brain barrier dysfunction through autophagy pathway and excessive erythrophagocytosisEun-Hye Kim0Seung Mi Baek1Han Jin Park2Yiying Bian3Han Young Chung4Ok-Nam Bae5College of Pharmacy Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan 15588, Republic of KoreaCollege of Pharmacy Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan 15588, Republic of KoreaCollege of Pharmacy Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan 15588, Republic of KoreaSchool of Public Health, China Medical University, Shenyang 110122, ChinaCollege of Pharmacy, Chungnam National University, Daejeon 34134, Republic of KoreaCollege of Pharmacy Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan 15588, Republic of Korea; Corresponding author.There is increasing concern regarding the risks posed by plastics to human health. Nano-sized plastics enter the body through various exposure routes. Although nano-sized particles circulate through the bloodstream and access the blood-brain barrier (BBB), the harmful impacts of nano-sized plastics on BBB function including endothelial cells are not well known. In this study, polystyrene nanoplastics (PS-NP) resulted in hyperpermeability and damaged tight junction proteins in brain endothelial cells. We identified that PS-NP increased intracellular iron levels by inhibiting the autophagy pathway in brain endothelial cells. Our study showed that dysregulated autophagy pathways led to increased BBB permeability induced by PS-NP treatment. In addition, PS-NP caused excessive erythrophagocytosis in brain endothelial cells via damaged red blood cells. PS-NP-treated RBCs (NP-RBC) induced the BBB dysfunction and increased intracellular iron levels and ferroptosis in brain endothelial cells. We provide novel insights into the potential risks of nano-sized plastics in BBB function by interaction between cells as well as direct exposure. Our study will help to understand the cardiovascular toxicity of nano-sized plastics.http://www.sciencedirect.com/science/article/pii/S0147651324015471Polystyrene nanoplasticsBlood-brain barrierEndothelial cellsErythrophagocytosis |
| spellingShingle | Eun-Hye Kim Seung Mi Baek Han Jin Park Yiying Bian Han Young Chung Ok-Nam Bae Polystyrene nanoplastics promote the blood-brain barrier dysfunction through autophagy pathway and excessive erythrophagocytosis Ecotoxicology and Environmental Safety Polystyrene nanoplastics Blood-brain barrier Endothelial cells Erythrophagocytosis |
| title | Polystyrene nanoplastics promote the blood-brain barrier dysfunction through autophagy pathway and excessive erythrophagocytosis |
| title_full | Polystyrene nanoplastics promote the blood-brain barrier dysfunction through autophagy pathway and excessive erythrophagocytosis |
| title_fullStr | Polystyrene nanoplastics promote the blood-brain barrier dysfunction through autophagy pathway and excessive erythrophagocytosis |
| title_full_unstemmed | Polystyrene nanoplastics promote the blood-brain barrier dysfunction through autophagy pathway and excessive erythrophagocytosis |
| title_short | Polystyrene nanoplastics promote the blood-brain barrier dysfunction through autophagy pathway and excessive erythrophagocytosis |
| title_sort | polystyrene nanoplastics promote the blood brain barrier dysfunction through autophagy pathway and excessive erythrophagocytosis |
| topic | Polystyrene nanoplastics Blood-brain barrier Endothelial cells Erythrophagocytosis |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324015471 |
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