Glucosinolates from Seed-Press Cake of <i>Camelina sativa</i> (L.) Crantz Extend Yeast Chronological Lifespan by Modulating Carbon Metabolism and Respiration

Glucosinolates from Seed-Press Cake of <i>Camelina sativa</i> (L.) Crantz Extend Yeast Chronological Lifespan by Modulating Carbon Metabolism and Respiration

Glucosinolates (GSLs) are nitrogen/sulfur-containing glycosides widely present in the order of Brassicales, particularly in the Brassicaceae family. Camelina (<i>Camelina sativa</i> (L.) Crantz) is an oilseed plant belonging to this family. Its seeds, in addition to a distinctive fatty a...

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Bibliographic Details
Main Authors: Francesco Abbiati, Ivan Orlandi, Stefania Pagliari, Luca Campone, Marina Vai
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Antioxidants
Subjects:
Camelina
glucosinolates
chronological aging
<i>Saccharomyces cerevisiae</i>
carbon metabolism
respiration
Online Access:https://www.mdpi.com/2076-3921/14/1/80
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Summary:Glucosinolates (GSLs) are nitrogen/sulfur-containing glycosides widely present in the order of Brassicales, particularly in the Brassicaceae family. Camelina (<i>Camelina sativa</i> (L.) Crantz) is an oilseed plant belonging to this family. Its seeds, in addition to a distinctive fatty acid composition, contain three aliphatic GSLs: glucoarabin, glucocamelinin, and homoglucocamelinin. Our study explored the impact of these GSLs purified from Camelina press cake, a by-product of Camelina oil production, on yeast chronological aging, which is the established model for simulating the aging of post-mitotic quiescent mammalian cells. Supplementing yeast cells with GSLs extends the chronological lifespan (CLS) in a dose-dependent manner. This enhancement relies on an improved mitochondrial respiration efficiency, resulting in a drastic decrease of superoxide anion levels and an increase in ATP production. Furthermore, GSL supplementation affects carbon metabolism. In particular, GSLs support the pro-longevity preservation of TCA cycle enzymatic activities and enhanced glycerol catabolism. These changes contribute positively to the phosphorylating respiration and to an increase in trehalose storage: both of which are longevity-promoting prerequisites.
ISSN:2076-3921

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