The RNA Binding Protein Bcas2 is Required for Antibody Class Switch in Activated‐B Cells

The RNA Binding Protein Bcas2 is Required for Antibody Class Switch in Activated‐B Cells

ABSTRACT In children, hyper‐IgM syndrome type 1 (HIGM1) is a type of severe antibody disorder, the pathogenesis of which remains unclear. The antibody diversity is partially determined by the alternative splicing (AS) in the germline, which is mainly regulated by RNA‐binding proteins, including Brea...

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Main Authors: Yu Chen, Siyuan Sun, Chenxu Lu, Yixuan Li, Bing Fang, Xiangfeng Tang, Xuepeng Li, Weiru Yu, Yumei Lei, Longjie Sun, Ming Zhang, Jiazeng Sun, Ping Liu, Yongting Luo, Xingwang Zhao, Jing Zhan, Libing Liu, Rong Liu, Jiaqiang Huang, Ziwei Yi, Yifei Yu, Weihan Xiao, Zheng Ding, Lei Li, Dan Su, Fazheng Ren, Changchang Cao, Ran Wang, Wenbiao Shi, Juan Chen
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Exploration
Subjects:
alternative splicing
Bcas2
class switch recombination
CLIP‐seq
hyper‐IgM syndrome type 1
RNA binding proteins
Online Access:https://doi.org/10.1002/EXP.70015
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