Programming for Stimulation-Induced Transient Nonmotor Psychiatric Symptoms after Bilateral Subthalamic Nucleus Deep Brain Stimulation for Parkinson’s Disease
Background. Stimulation-induced transient nonmotor psychiatric symptoms (STPSs) are side effects following bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson’s disease (PD) patients. We designed algorithms which (1) determine the electrode contacts that induce STPSs and (2)...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2017/2615619 |
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| author | Xi Wu Yiqing Qiu Keith Simfukwe Jiali Wang Jianchun Chen Xiaowu Hu |
| author_facet | Xi Wu Yiqing Qiu Keith Simfukwe Jiali Wang Jianchun Chen Xiaowu Hu |
| author_sort | Xi Wu |
| collection | DOAJ |
| description | Background. Stimulation-induced transient nonmotor psychiatric symptoms (STPSs) are side effects following bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson’s disease (PD) patients. We designed algorithms which (1) determine the electrode contacts that induce STPSs and (2) provide a programming protocol to eliminate STPS and maintain the optimal motor functions. Our objective is to test the effectiveness of these algorithms. Materials and Methods. 454 PD patients who underwent programming sessions after STN-DBS implantations were retrospectively analyzed. Only STPS patients were enrolled. In these patients, the contacts inducing STPS were found and the programming protocol algorithms used. Results. Eleven patients were diagnosed with STPS. Of these patients, two had four episodes of crying, and two had four episodes of mirthful laughter. In one patient, two episodes of abnormal sense of spatial orientation were observed. Hallucination episodes were observed twice in one patient, while five patients recorded eight episodes of hypomania. There were no statistical differences between the UPDRS-III under the final stimulation parameter (without STPS) and previous optimum UPDRS-III under the STPSs (p=1.000). Conclusion. The flow diagram used for determining electrode contacts that induce STPS and the programming protocol employed in the treatment of these symptoms are effective. |
| format | Article |
| id | doaj-art-5107e90c886947cf8e75c9c4a3887cc4 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-5107e90c886947cf8e75c9c4a3887cc42025-02-03T05:45:43ZengWileyParkinson's Disease2090-80832042-00802017-01-01201710.1155/2017/26156192615619Programming for Stimulation-Induced Transient Nonmotor Psychiatric Symptoms after Bilateral Subthalamic Nucleus Deep Brain Stimulation for Parkinson’s DiseaseXi Wu0Yiqing Qiu1Keith Simfukwe2Jiali Wang3Jianchun Chen4Xiaowu Hu5Department of Neurosurgery, Second Military Medical University, Changhai Hospital, No. 168 Changhai Road, Yangpu District, Shanghai, ChinaDepartment of Neurosurgery, Second Military Medical University, Changhai Hospital, No. 168 Changhai Road, Yangpu District, Shanghai, ChinaDepartment of Neurosurgery, Changhai Hospital, Second Military Medical University, International College of Exchange, No. 800 Xiangyin Road, Shanghai 200433, ChinaDepartment of Neurosurgery, Second Military Medical University, Changhai Hospital, No. 168 Changhai Road, Yangpu District, Shanghai, ChinaDepartment of Neurosurgery, Second Military Medical University, Changhai Hospital, No. 168 Changhai Road, Yangpu District, Shanghai, ChinaDepartment of Neurosurgery, Second Military Medical University, Changhai Hospital, No. 168 Changhai Road, Yangpu District, Shanghai, ChinaBackground. Stimulation-induced transient nonmotor psychiatric symptoms (STPSs) are side effects following bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson’s disease (PD) patients. We designed algorithms which (1) determine the electrode contacts that induce STPSs and (2) provide a programming protocol to eliminate STPS and maintain the optimal motor functions. Our objective is to test the effectiveness of these algorithms. Materials and Methods. 454 PD patients who underwent programming sessions after STN-DBS implantations were retrospectively analyzed. Only STPS patients were enrolled. In these patients, the contacts inducing STPS were found and the programming protocol algorithms used. Results. Eleven patients were diagnosed with STPS. Of these patients, two had four episodes of crying, and two had four episodes of mirthful laughter. In one patient, two episodes of abnormal sense of spatial orientation were observed. Hallucination episodes were observed twice in one patient, while five patients recorded eight episodes of hypomania. There were no statistical differences between the UPDRS-III under the final stimulation parameter (without STPS) and previous optimum UPDRS-III under the STPSs (p=1.000). Conclusion. The flow diagram used for determining electrode contacts that induce STPS and the programming protocol employed in the treatment of these symptoms are effective.http://dx.doi.org/10.1155/2017/2615619 |
| spellingShingle | Xi Wu Yiqing Qiu Keith Simfukwe Jiali Wang Jianchun Chen Xiaowu Hu Programming for Stimulation-Induced Transient Nonmotor Psychiatric Symptoms after Bilateral Subthalamic Nucleus Deep Brain Stimulation for Parkinson’s Disease Parkinson's Disease |
| title | Programming for Stimulation-Induced Transient Nonmotor Psychiatric Symptoms after Bilateral Subthalamic Nucleus Deep Brain Stimulation for Parkinson’s Disease |
| title_full | Programming for Stimulation-Induced Transient Nonmotor Psychiatric Symptoms after Bilateral Subthalamic Nucleus Deep Brain Stimulation for Parkinson’s Disease |
| title_fullStr | Programming for Stimulation-Induced Transient Nonmotor Psychiatric Symptoms after Bilateral Subthalamic Nucleus Deep Brain Stimulation for Parkinson’s Disease |
| title_full_unstemmed | Programming for Stimulation-Induced Transient Nonmotor Psychiatric Symptoms after Bilateral Subthalamic Nucleus Deep Brain Stimulation for Parkinson’s Disease |
| title_short | Programming for Stimulation-Induced Transient Nonmotor Psychiatric Symptoms after Bilateral Subthalamic Nucleus Deep Brain Stimulation for Parkinson’s Disease |
| title_sort | programming for stimulation induced transient nonmotor psychiatric symptoms after bilateral subthalamic nucleus deep brain stimulation for parkinson s disease |
| url | http://dx.doi.org/10.1155/2017/2615619 |
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