The Toll of Vascular Insufficiency: Implications for the Management of Peripheral Arterial Disease
Peripheral artery disease (PAD) can result in limb loss within six months of diagnosis in a subset of patients who cannot undergo endovascular or surgical revascularization yet continues to maintain a marginal position in cardiovascular research. While a body of literature continues to grow describi...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/8249015 |
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| _version_ | 1832554218401038336 |
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| author | Jun Xu Ulka Sachdev |
| author_facet | Jun Xu Ulka Sachdev |
| author_sort | Jun Xu |
| collection | DOAJ |
| description | Peripheral artery disease (PAD) can result in limb loss within six months of diagnosis in a subset of patients who cannot undergo endovascular or surgical revascularization yet continues to maintain a marginal position in cardiovascular research. While a body of literature continues to grow describing the role of danger signaling and innate immunity in cardiac biology, the role of these pathways in the ischemic myopathy associated with PAD has not been extensively studied. The following report will review the current literature on the role of Toll-like receptor (TLR) signaling in cardiovascular biology as well as in nonischemic myopathy. While attenuation of TLR signaling has not been shown to be clinically useful in the treatment of infectious inflammation, it may show promise in the management of severe arterial insufficiency. |
| format | Article |
| id | doaj-art-50fbb22796104bd29565c85b32acdfca |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-50fbb22796104bd29565c85b32acdfca2025-02-03T05:52:07ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/82490158249015The Toll of Vascular Insufficiency: Implications for the Management of Peripheral Arterial DiseaseJun Xu0Ulka Sachdev1Division of Vascular Surgery, University of Pittsburgh Medical Center, 200 Lothrop Street, Suite A1011, Pittsburgh, PA 15213, USADivision of Vascular Surgery, University of Pittsburgh Medical Center, 200 Lothrop Street, Suite A1011, Pittsburgh, PA 15213, USAPeripheral artery disease (PAD) can result in limb loss within six months of diagnosis in a subset of patients who cannot undergo endovascular or surgical revascularization yet continues to maintain a marginal position in cardiovascular research. While a body of literature continues to grow describing the role of danger signaling and innate immunity in cardiac biology, the role of these pathways in the ischemic myopathy associated with PAD has not been extensively studied. The following report will review the current literature on the role of Toll-like receptor (TLR) signaling in cardiovascular biology as well as in nonischemic myopathy. While attenuation of TLR signaling has not been shown to be clinically useful in the treatment of infectious inflammation, it may show promise in the management of severe arterial insufficiency.http://dx.doi.org/10.1155/2016/8249015 |
| spellingShingle | Jun Xu Ulka Sachdev The Toll of Vascular Insufficiency: Implications for the Management of Peripheral Arterial Disease Journal of Immunology Research |
| title | The Toll of Vascular Insufficiency: Implications for the Management of Peripheral Arterial Disease |
| title_full | The Toll of Vascular Insufficiency: Implications for the Management of Peripheral Arterial Disease |
| title_fullStr | The Toll of Vascular Insufficiency: Implications for the Management of Peripheral Arterial Disease |
| title_full_unstemmed | The Toll of Vascular Insufficiency: Implications for the Management of Peripheral Arterial Disease |
| title_short | The Toll of Vascular Insufficiency: Implications for the Management of Peripheral Arterial Disease |
| title_sort | toll of vascular insufficiency implications for the management of peripheral arterial disease |
| url | http://dx.doi.org/10.1155/2016/8249015 |
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