Cdk6’s functions are critically regulated by its unique C-terminus

Cdk6’s functions are critically regulated by its unique C-terminus

Summary: The vital cell cycle machinery is tightly regulated and alterations of its central signaling hubs are a hallmark of cancer. The activity of CDK6 is controlled by interaction with several partners including cyclins and INK4 proteins, which have been shown to mainly bind to the amino-terminal...

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Bibliographic Details
Main Authors: Alessia Schirripa, Helge Schöppe, Sofie Nebenfuehr, Markus Zojer, Thorsten Klampfl, Valentina Kugler, Belinda S. Maw, Huriye Ceylan, Iris Z. Uras, Lisa Scheiblecker, Elisabeth Gamper, Ulrich Stelzl, Eduard Stefan, Teresa Kaserer, Veronika Sexl, Karoline Kollmann
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:iScience
Subjects:
Biochemistry
Molecular Structure
Structural biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224029249
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