Cell deconvolution-based integrated time-series network of whole blood transcriptome reveals systemic antiviral activities and cell-specific immunological changes against PRRSV infection

Cell deconvolution-based integrated time-series network of whole blood transcriptome reveals systemic antiviral activities and cell-specific immunological changes against PRRSV infection

Abstract Porcine reproductive and respiratory syndrome (PRRS) causes significant economic losses in the swine industry. However, the molecular mechanisms behind the common and cell type-specific systemic responses during PRRS virus (PRRSV) infection are not well understood. In this study, we collect...

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Bibliographic Details
Main Authors: Byeonghwi Lim, Chiwoong Lim, Min-Jae Jang, Young-Jun Seo, Do-Young Kim, Christopher K. Tuggle, Kyu-Sang Lim, Jun-Mo Kim
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Veterinary Research
Subjects:
PRRS virus
whole blood
RNA sequencing
cell deconvolution
transcriptomics
time-series network
Online Access:https://doi.org/10.1186/s13567-025-01451-w
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