Does Pseudomonas aeruginosa Colonization Affect Exercise Capacity in CF?
Introduction. Cardio-Pulmonary Exercise Testing (CPET) has been recognized as a valuable method in assessing disease burden and exercise capacity among CF patients. Aim. To evaluate whether Pseudomonas aeruginosa colonization status affects Exercise Capacity, LCI and High-Resolution Computed Tomogra...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2019/3786245 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565506475819008 |
|---|---|
| author | Asterios Kampouras Elpis Hatziagorou Vasiliki Avramidou Vasiliki Georgopoulou Fotios Kirvassilis John Tsanakas |
| author_facet | Asterios Kampouras Elpis Hatziagorou Vasiliki Avramidou Vasiliki Georgopoulou Fotios Kirvassilis John Tsanakas |
| author_sort | Asterios Kampouras |
| collection | DOAJ |
| description | Introduction. Cardio-Pulmonary Exercise Testing (CPET) has been recognized as a valuable method in assessing disease burden and exercise capacity among CF patients. Aim. To evaluate whether Pseudomonas aeruginosa colonization status affects Exercise Capacity, LCI and High-Resolution Computed Tomography (HRCT) indices among patients with CF; to check if Pseudomonas colonization can predict exercise intolerance. Subjects. Seventy-eight (78) children and adults with CF (31 males) mean (range) age 17.08 (6.75; 24.25) performed spirometry, Multiple Breath Washout (MBW) and CPET along with HRCT on the same day during their admission or follow up visit. Results. 78 CF patients (mean FEV1: 83.3% mean LCI: 10.9 and mean VO2 peak: 79.1%) were evaluated: 33 were chronically colonized with Pseudomonas aeruginosa, 24 were intermittently colonized whereas 21 were Pseudomonas free. Statistically significant differences were observed among the three groups in: peak oxygen uptake % predicted (VO2 peak% (p<0.001), LCI (p<0.001), as well as FEV1% (p<0.001) and FVC% (p<0.001). Pseudomonas colonization could predict VO2 peak% (p<0.001, r2: −0.395). Conclusion. Exercise capacity as reflected by peak oxygen uptake is reduced in Pseudomonas colonized patients and reflects lung structural damages as shown on HRCT. Pseudomonas colonization could predict exercise limitation among CF patients. |
| format | Article |
| id | doaj-art-50e95bdd663243f8994377e277bca0be |
| institution | Kabale University |
| issn | 2090-1836 2090-1844 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-50e95bdd663243f8994377e277bca0be2025-02-03T01:07:26ZengWileyPulmonary Medicine2090-18362090-18442019-01-01201910.1155/2019/37862453786245Does Pseudomonas aeruginosa Colonization Affect Exercise Capacity in CF?Asterios Kampouras0Elpis Hatziagorou1Vasiliki Avramidou2Vasiliki Georgopoulou3Fotios Kirvassilis4John Tsanakas5Pediatric Pulmonology and CF Unit, 3rd Department of Pediatrics, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, GreecePediatric Pulmonology and CF Unit, 3rd Department of Pediatrics, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, GreecePediatric Pulmonology and CF Unit, 3rd Department of Pediatrics, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, GreeceRadiology Department, Hippokration Hospital, Thessaloniki, GreecePediatric Pulmonology and CF Unit, 3rd Department of Pediatrics, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, GreecePediatric Pulmonology and CF Unit, 3rd Department of Pediatrics, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, GreeceIntroduction. Cardio-Pulmonary Exercise Testing (CPET) has been recognized as a valuable method in assessing disease burden and exercise capacity among CF patients. Aim. To evaluate whether Pseudomonas aeruginosa colonization status affects Exercise Capacity, LCI and High-Resolution Computed Tomography (HRCT) indices among patients with CF; to check if Pseudomonas colonization can predict exercise intolerance. Subjects. Seventy-eight (78) children and adults with CF (31 males) mean (range) age 17.08 (6.75; 24.25) performed spirometry, Multiple Breath Washout (MBW) and CPET along with HRCT on the same day during their admission or follow up visit. Results. 78 CF patients (mean FEV1: 83.3% mean LCI: 10.9 and mean VO2 peak: 79.1%) were evaluated: 33 were chronically colonized with Pseudomonas aeruginosa, 24 were intermittently colonized whereas 21 were Pseudomonas free. Statistically significant differences were observed among the three groups in: peak oxygen uptake % predicted (VO2 peak% (p<0.001), LCI (p<0.001), as well as FEV1% (p<0.001) and FVC% (p<0.001). Pseudomonas colonization could predict VO2 peak% (p<0.001, r2: −0.395). Conclusion. Exercise capacity as reflected by peak oxygen uptake is reduced in Pseudomonas colonized patients and reflects lung structural damages as shown on HRCT. Pseudomonas colonization could predict exercise limitation among CF patients.http://dx.doi.org/10.1155/2019/3786245 |
| spellingShingle | Asterios Kampouras Elpis Hatziagorou Vasiliki Avramidou Vasiliki Georgopoulou Fotios Kirvassilis John Tsanakas Does Pseudomonas aeruginosa Colonization Affect Exercise Capacity in CF? Pulmonary Medicine |
| title | Does Pseudomonas aeruginosa Colonization Affect Exercise Capacity in CF? |
| title_full | Does Pseudomonas aeruginosa Colonization Affect Exercise Capacity in CF? |
| title_fullStr | Does Pseudomonas aeruginosa Colonization Affect Exercise Capacity in CF? |
| title_full_unstemmed | Does Pseudomonas aeruginosa Colonization Affect Exercise Capacity in CF? |
| title_short | Does Pseudomonas aeruginosa Colonization Affect Exercise Capacity in CF? |
| title_sort | does pseudomonas aeruginosa colonization affect exercise capacity in cf |
| url | http://dx.doi.org/10.1155/2019/3786245 |
| work_keys_str_mv | AT asterioskampouras doespseudomonasaeruginosacolonizationaffectexercisecapacityincf AT elpishatziagorou doespseudomonasaeruginosacolonizationaffectexercisecapacityincf AT vasilikiavramidou doespseudomonasaeruginosacolonizationaffectexercisecapacityincf AT vasilikigeorgopoulou doespseudomonasaeruginosacolonizationaffectexercisecapacityincf AT fotioskirvassilis doespseudomonasaeruginosacolonizationaffectexercisecapacityincf AT johntsanakas doespseudomonasaeruginosacolonizationaffectexercisecapacityincf |