Attitudes to Medication after Kidney Transplantation and Their Association with Medication Adherence and Graft Survival: A 2-Year Follow-Up Study
Background. Nonadherence to medication is a common problem after kidney transplantation. The aim of this study was to explore attitudes towards medication, adherence, and the relationship with clinical outcomes. Method. Kidney recipients participated in a Q-methodological study 6 weeks after transpl...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2014/675301 |
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| author | Mirjam Tielen Job van Exel Mirjam Laging Denise K. Beck Roshni Khemai Teun van Gelder Michiel G. H. Betjes Willem Weimar Emma K. Massey |
| author_facet | Mirjam Tielen Job van Exel Mirjam Laging Denise K. Beck Roshni Khemai Teun van Gelder Michiel G. H. Betjes Willem Weimar Emma K. Massey |
| author_sort | Mirjam Tielen |
| collection | DOAJ |
| description | Background. Nonadherence to medication is a common problem after kidney transplantation. The aim of this study was to explore attitudes towards medication, adherence, and the relationship with clinical outcomes. Method. Kidney recipients participated in a Q-methodological study 6 weeks after transplantation. As a measure of medication adherence, respondents completed the Basel Assessment of Adherence to Immunosuppressive Medications Scale (BAASIS©-interview). Moreover, the intrapatient variability in the pharmacokinetics of tacrolimus was calculated, which measures stability of drug intake. Data on graft survival was retrieved from patient records up to 2 years after transplantation. Results. 113 renal transplant recipients (19–75 years old) participated in the study. Results revealed three attitudes towards medication adherence—attitude 1: “confident and accurate,” attitude 2: “concerned and vigilant,” and attitude 3: “appearance oriented and assertive.” We found association of attitudes with intrapatient variability in pharmacokinetics of tacrolimus, but not with self-reported nonadherence or graft survival. However, self-reported nonadherence immediately after transplantation was associated with lower two-year graft survival.
Conclusion. These preliminary findings suggest that nonadherence shortly after kidney transplantation may be a risk factor for lower graft survival in the years to follow. The attitudes to medication were not a risk factor. |
| format | Article |
| id | doaj-art-50e3dccfc5684b018c856298b7625acd |
| institution | Kabale University |
| issn | 2090-0007 2090-0015 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-50e3dccfc5684b018c856298b7625acd2025-02-03T07:24:29ZengWileyJournal of Transplantation2090-00072090-00152014-01-01201410.1155/2014/675301675301Attitudes to Medication after Kidney Transplantation and Their Association with Medication Adherence and Graft Survival: A 2-Year Follow-Up StudyMirjam Tielen0Job van Exel1Mirjam Laging2Denise K. Beck3Roshni Khemai4Teun van Gelder5Michiel G. H. Betjes6Willem Weimar7Emma K. Massey8Department of Internal Medicine, Erasmus Medical Centre, P.O. Box 2040, 3000 CA Rotterdam, The NetherlandsInstitute of Health Policy & Management (iBMG), Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The NetherlandsDepartment of Internal Medicine, Erasmus Medical Centre, P.O. Box 2040, 3000 CA Rotterdam, The NetherlandsDepartment of Internal Medicine, Erasmus Medical Centre, P.O. Box 2040, 3000 CA Rotterdam, The NetherlandsDepartment of Internal Medicine, Erasmus Medical Centre, P.O. Box 2040, 3000 CA Rotterdam, The NetherlandsDepartment of Internal Medicine, Erasmus Medical Centre, P.O. Box 2040, 3000 CA Rotterdam, The NetherlandsDepartment of Internal Medicine, Erasmus Medical Centre, P.O. Box 2040, 3000 CA Rotterdam, The NetherlandsDepartment of Internal Medicine, Erasmus Medical Centre, P.O. Box 2040, 3000 CA Rotterdam, The NetherlandsDepartment of Internal Medicine, Erasmus Medical Centre, P.O. Box 2040, 3000 CA Rotterdam, The NetherlandsBackground. Nonadherence to medication is a common problem after kidney transplantation. The aim of this study was to explore attitudes towards medication, adherence, and the relationship with clinical outcomes. Method. Kidney recipients participated in a Q-methodological study 6 weeks after transplantation. As a measure of medication adherence, respondents completed the Basel Assessment of Adherence to Immunosuppressive Medications Scale (BAASIS©-interview). Moreover, the intrapatient variability in the pharmacokinetics of tacrolimus was calculated, which measures stability of drug intake. Data on graft survival was retrieved from patient records up to 2 years after transplantation. Results. 113 renal transplant recipients (19–75 years old) participated in the study. Results revealed three attitudes towards medication adherence—attitude 1: “confident and accurate,” attitude 2: “concerned and vigilant,” and attitude 3: “appearance oriented and assertive.” We found association of attitudes with intrapatient variability in pharmacokinetics of tacrolimus, but not with self-reported nonadherence or graft survival. However, self-reported nonadherence immediately after transplantation was associated with lower two-year graft survival. Conclusion. These preliminary findings suggest that nonadherence shortly after kidney transplantation may be a risk factor for lower graft survival in the years to follow. The attitudes to medication were not a risk factor.http://dx.doi.org/10.1155/2014/675301 |
| spellingShingle | Mirjam Tielen Job van Exel Mirjam Laging Denise K. Beck Roshni Khemai Teun van Gelder Michiel G. H. Betjes Willem Weimar Emma K. Massey Attitudes to Medication after Kidney Transplantation and Their Association with Medication Adherence and Graft Survival: A 2-Year Follow-Up Study Journal of Transplantation |
| title | Attitudes to Medication after Kidney Transplantation and Their Association with Medication Adherence and Graft Survival: A 2-Year Follow-Up Study |
| title_full | Attitudes to Medication after Kidney Transplantation and Their Association with Medication Adherence and Graft Survival: A 2-Year Follow-Up Study |
| title_fullStr | Attitudes to Medication after Kidney Transplantation and Their Association with Medication Adherence and Graft Survival: A 2-Year Follow-Up Study |
| title_full_unstemmed | Attitudes to Medication after Kidney Transplantation and Their Association with Medication Adherence and Graft Survival: A 2-Year Follow-Up Study |
| title_short | Attitudes to Medication after Kidney Transplantation and Their Association with Medication Adherence and Graft Survival: A 2-Year Follow-Up Study |
| title_sort | attitudes to medication after kidney transplantation and their association with medication adherence and graft survival a 2 year follow up study |
| url | http://dx.doi.org/10.1155/2014/675301 |
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