Long-term functioning status of COVID-19 survivors: a prospective observational evaluation of a cohort of patients surviving hospitalisation
Objectives The study investigated the long-term functional status of hospitalised COVID-19 survivors to explore and document their functional situation.Design This prospective observational study assessed 801 COVID-19 survivors at 3–11 months after hospital discharge. It analyses participants'...
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BMJ Publishing Group
2022-07-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/7/e057246.full |
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| author | Linamara Rizzo Battistella Felipe Fregni Marta Imamura Vinicius Delgado Ramos Lucas Ramos De Pretto Simon K H A A Van Cauwenbergh Sabrina Saemy Tome Uchiyama Denise Matheus Flavia Kuhn Ana Alice Amaral de Oliveira Gabriella Souza Naves Aline Rossetti Mirisola Fernando de Quadros Ribeiro Andre Tadeu Sugawara Mauricio Cantarino Rafael Andrade Santos Antunes Cavalca Vanessa Pagano Melina Valentim Marques Elizabeth Mendes da Silva Alessandra Pereira Gomes |
| author_facet | Linamara Rizzo Battistella Felipe Fregni Marta Imamura Vinicius Delgado Ramos Lucas Ramos De Pretto Simon K H A A Van Cauwenbergh Sabrina Saemy Tome Uchiyama Denise Matheus Flavia Kuhn Ana Alice Amaral de Oliveira Gabriella Souza Naves Aline Rossetti Mirisola Fernando de Quadros Ribeiro Andre Tadeu Sugawara Mauricio Cantarino Rafael Andrade Santos Antunes Cavalca Vanessa Pagano Melina Valentim Marques Elizabeth Mendes da Silva Alessandra Pereira Gomes |
| author_sort | Linamara Rizzo Battistella |
| collection | DOAJ |
| description | Objectives The study investigated the long-term functional status of hospitalised COVID-19 survivors to explore and document their functional situation.Design This prospective observational study assessed 801 COVID-19 survivors at 3–11 months after hospital discharge. It analyses participants' sociodemographic background, COVID-19 clinical manifestations, and clinical and functional evaluations.Setting Tertiary-level university hospital in São Paulo, Brazil.Participants Study participants are COVID-19 survivors admitted to hospital care for at least 24 hours to treat acute SARS-CoV-2 infection.Outcome measures Epworth Sleepiness Scale, EuroQoL-5 Dimensions-5 Levels, Functional Assessment of Chronic Illness Therapy–Fatigue, Functional Independence Measure, Functional Oral Intake Scale, Handgrip Strength, Insomnia Severity Index, Medical Research Council (MRC) Dyspnea Scale, MRC sum score, Modified Borg Dyspnea Scale, pain Visual Analogue Scale, Post-COVID-19 Functional Status, Timed Up and Go, WHO Disability Assessment Schedule 2.0, 1-Minute Sit to Stand Test.Results Many participants required invasive mechanical ventilation (41.57%, 333 of 801). Mean age was 55.35±14.58 years. With a mean of 6.56 (SD: 1.58; 95% CI: 6.45 to 6.67) months after hospital discharge, 70.86% (567 of 800) reported limited daily activities, which were severe in 5.62% (45 of 800). They also reported pain and discomfort (64.50%, 516 of 800), breathlessness (64.66%, 514 of 795), and anxiety and depression (57.27%, 457 of 798). Daytime sleepiness and insomnia evaluations showed subthreshold results. Most (92.85%, 727 of 783) participants reported unrestricted oral intake. Data indicated no generalised fatigue (mean score: 39.18, SD: 9.77; 95% CI: 38.50 to 39.86). Assessments showed poor handgrip strength (52.20%, 379 of 726) and abnormal Timed Up and Go results (mean 13.07 s, SD: 6.49). The invasive mechanical ventilation group seemed to have a better handgrip strength however. We found no clear trends of change in their functional status during months passed since hospital discharge.Conclusions Muscle weakness, pain, anxiety, depression, breathlessness, reduced mobility, insomnia and daytime sleepiness were the most prevalent long-term conditions identified among previously hospitalised COVID-19 survivors. |
| format | Article |
| id | doaj-art-50d61ad919a541f48f955dab44f9d75a |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-50d61ad919a541f48f955dab44f9d75a2025-01-31T12:55:09ZengBMJ Publishing GroupBMJ Open2044-60552022-07-0112710.1136/bmjopen-2021-057246Long-term functioning status of COVID-19 survivors: a prospective observational evaluation of a cohort of patients surviving hospitalisationLinamara Rizzo Battistella0Felipe Fregni1Marta Imamura2Vinicius Delgado Ramos3Lucas Ramos De Pretto4Simon K H A A Van Cauwenbergh5Sabrina Saemy Tome Uchiyama6Denise Matheus7Flavia Kuhn8Ana Alice Amaral de Oliveira9Gabriella Souza Naves10Aline Rossetti Mirisola11Fernando de Quadros Ribeiro12Andre Tadeu Sugawara13Mauricio Cantarino14Rafael Andrade Santos Antunes Cavalca15Vanessa Pagano16Melina Valentim Marques17Elizabeth Mendes da Silva18Alessandra Pereira Gomes192 Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, BrazilDepartment of Physical Medicine and Rehabilitation, Massachusetts General Hospital, Boston, Massachusetts, USAFaculdade de Medicina FMUSP, Universidade de Sao Paulo, São Paulo, SP, BrazilInstituto de Medicina Física e Reabilitação, Hospital das Clinicas HCFMUSP, São Paulo, SP, BrazilCenter for Lasers and Applications, Energy and Nuclear Research Institute, São Paulo, SP, BrazilFaculdade de Medicina FMUSP, Universidade de Sao Paulo, São Paulo, SP, BrazilInstituto de Medicina Física e Reabilitação, Hospital das Clinicas HCFMUSP, São Paulo, SP, BrazilInstituto de Medicina Física e Reabilitação, Hospital das Clinicas HCFMUSP, São Paulo, SP, BrazilInstituto de Medicina Física e Reabilitação, Hospital das Clinicas HCFMUSP, São Paulo, SP, BrazilInstituto de Medicina Física e Reabilitação, Hospital das Clinicas HCFMUSP, São Paulo, SP, BrazilInstituto de Medicina Física e Reabilitação, Hospital das Clinicas HCFMUSP, São Paulo, SP, BrazilInstituto de Medicina Física e Reabilitação, Hospital das Clinicas HCFMUSP, São Paulo, SP, BrazilInstituto de Medicina Física e Reabilitação, Hospital das Clinicas HCFMUSP, São Paulo, SP, BrazilInstituto de Medicina Física e Reabilitação, Hospital das Clinicas HCFMUSP, São Paulo, SP, BrazilInstituto de Medicina Física e Reabilitação, Hospital das Clinicas HCFMUSP, São Paulo, SP, BrazilInstituto de Medicina Física e Reabilitação, Hospital das Clinicas HCFMUSP, São Paulo, SP, BrazilInstituto de Medicina Física e Reabilitação, Hospital das Clinicas HCFMUSP, São Paulo, SP, BrazilInstituto de Medicina Física e Reabilitação, Hospital das Clinicas HCFMUSP, São Paulo, SP, BrazilInstituto de Medicina Física e Reabilitação, Hospital das Clinicas HCFMUSP, São Paulo, SP, BrazilInstituto de Medicina Física e Reabilitação, Hospital das Clinicas HCFMUSP, São Paulo, SP, BrazilObjectives The study investigated the long-term functional status of hospitalised COVID-19 survivors to explore and document their functional situation.Design This prospective observational study assessed 801 COVID-19 survivors at 3–11 months after hospital discharge. It analyses participants' sociodemographic background, COVID-19 clinical manifestations, and clinical and functional evaluations.Setting Tertiary-level university hospital in São Paulo, Brazil.Participants Study participants are COVID-19 survivors admitted to hospital care for at least 24 hours to treat acute SARS-CoV-2 infection.Outcome measures Epworth Sleepiness Scale, EuroQoL-5 Dimensions-5 Levels, Functional Assessment of Chronic Illness Therapy–Fatigue, Functional Independence Measure, Functional Oral Intake Scale, Handgrip Strength, Insomnia Severity Index, Medical Research Council (MRC) Dyspnea Scale, MRC sum score, Modified Borg Dyspnea Scale, pain Visual Analogue Scale, Post-COVID-19 Functional Status, Timed Up and Go, WHO Disability Assessment Schedule 2.0, 1-Minute Sit to Stand Test.Results Many participants required invasive mechanical ventilation (41.57%, 333 of 801). Mean age was 55.35±14.58 years. With a mean of 6.56 (SD: 1.58; 95% CI: 6.45 to 6.67) months after hospital discharge, 70.86% (567 of 800) reported limited daily activities, which were severe in 5.62% (45 of 800). They also reported pain and discomfort (64.50%, 516 of 800), breathlessness (64.66%, 514 of 795), and anxiety and depression (57.27%, 457 of 798). Daytime sleepiness and insomnia evaluations showed subthreshold results. Most (92.85%, 727 of 783) participants reported unrestricted oral intake. Data indicated no generalised fatigue (mean score: 39.18, SD: 9.77; 95% CI: 38.50 to 39.86). Assessments showed poor handgrip strength (52.20%, 379 of 726) and abnormal Timed Up and Go results (mean 13.07 s, SD: 6.49). The invasive mechanical ventilation group seemed to have a better handgrip strength however. We found no clear trends of change in their functional status during months passed since hospital discharge.Conclusions Muscle weakness, pain, anxiety, depression, breathlessness, reduced mobility, insomnia and daytime sleepiness were the most prevalent long-term conditions identified among previously hospitalised COVID-19 survivors.https://bmjopen.bmj.com/content/12/7/e057246.full |
| spellingShingle | Linamara Rizzo Battistella Felipe Fregni Marta Imamura Vinicius Delgado Ramos Lucas Ramos De Pretto Simon K H A A Van Cauwenbergh Sabrina Saemy Tome Uchiyama Denise Matheus Flavia Kuhn Ana Alice Amaral de Oliveira Gabriella Souza Naves Aline Rossetti Mirisola Fernando de Quadros Ribeiro Andre Tadeu Sugawara Mauricio Cantarino Rafael Andrade Santos Antunes Cavalca Vanessa Pagano Melina Valentim Marques Elizabeth Mendes da Silva Alessandra Pereira Gomes Long-term functioning status of COVID-19 survivors: a prospective observational evaluation of a cohort of patients surviving hospitalisation BMJ Open |
| title | Long-term functioning status of COVID-19 survivors: a prospective observational evaluation of a cohort of patients surviving hospitalisation |
| title_full | Long-term functioning status of COVID-19 survivors: a prospective observational evaluation of a cohort of patients surviving hospitalisation |
| title_fullStr | Long-term functioning status of COVID-19 survivors: a prospective observational evaluation of a cohort of patients surviving hospitalisation |
| title_full_unstemmed | Long-term functioning status of COVID-19 survivors: a prospective observational evaluation of a cohort of patients surviving hospitalisation |
| title_short | Long-term functioning status of COVID-19 survivors: a prospective observational evaluation of a cohort of patients surviving hospitalisation |
| title_sort | long term functioning status of covid 19 survivors a prospective observational evaluation of a cohort of patients surviving hospitalisation |
| url | https://bmjopen.bmj.com/content/12/7/e057246.full |
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