Newer Clinical Strategies for Combining Interferon and Cytotoxic Agents Against Solid Tumours and Hematological Malignancies
The role of interferons in the treatment of cancer continues to evolve. Despite limited single agent activity against solid tumours, interferons now appear to have an important role as modulators of the activity of a variety of cytotoxic drugs. Clinical benefits have been observed for combinations o...
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| Format: | Article |
| Language: | English |
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Wiley
1994-01-01
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| Series: | Canadian Journal of Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/1994/474259 |
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| _version_ | 1832545366973612032 |
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| author | Scott Wadler |
| author_facet | Scott Wadler |
| author_sort | Scott Wadler |
| collection | DOAJ |
| description | The role of interferons in the treatment of cancer continues to evolve. Despite limited single agent activity against solid tumours, interferons now appear to have an important role as modulators of the activity of a variety of cytotoxic drugs. Clinical benefits have been observed for combinations of interferons and alkylating agents against low grade lymphomas, interferons and dacarbazine against malignant melanoma, and interferons and 5-fluorouracil against gastrointestinal and genitourinary malignancies. Further progress will depend on a grealer understanding of the biology of the interaction. |
| format | Article |
| id | doaj-art-50d5b4ab8826439aa78b28a3ffca2aa1 |
| institution | Kabale University |
| issn | 1180-2332 |
| language | English |
| publishDate | 1994-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases |
| spelling | doaj-art-50d5b4ab8826439aa78b28a3ffca2aa12025-02-03T07:26:01ZengWileyCanadian Journal of Infectious Diseases1180-23321994-01-015Suppl A17A22A10.1155/1994/474259Newer Clinical Strategies for Combining Interferon and Cytotoxic Agents Against Solid Tumours and Hematological MalignanciesScott Wadler0Albert Einstein Cancer Center and the Department of Oncology, Montefiore Medical Center, Bronx, New York, USAThe role of interferons in the treatment of cancer continues to evolve. Despite limited single agent activity against solid tumours, interferons now appear to have an important role as modulators of the activity of a variety of cytotoxic drugs. Clinical benefits have been observed for combinations of interferons and alkylating agents against low grade lymphomas, interferons and dacarbazine against malignant melanoma, and interferons and 5-fluorouracil against gastrointestinal and genitourinary malignancies. Further progress will depend on a grealer understanding of the biology of the interaction.http://dx.doi.org/10.1155/1994/474259 |
| spellingShingle | Scott Wadler Newer Clinical Strategies for Combining Interferon and Cytotoxic Agents Against Solid Tumours and Hematological Malignancies Canadian Journal of Infectious Diseases |
| title | Newer Clinical Strategies for Combining Interferon and Cytotoxic Agents Against Solid Tumours and Hematological Malignancies |
| title_full | Newer Clinical Strategies for Combining Interferon and Cytotoxic Agents Against Solid Tumours and Hematological Malignancies |
| title_fullStr | Newer Clinical Strategies for Combining Interferon and Cytotoxic Agents Against Solid Tumours and Hematological Malignancies |
| title_full_unstemmed | Newer Clinical Strategies for Combining Interferon and Cytotoxic Agents Against Solid Tumours and Hematological Malignancies |
| title_short | Newer Clinical Strategies for Combining Interferon and Cytotoxic Agents Against Solid Tumours and Hematological Malignancies |
| title_sort | newer clinical strategies for combining interferon and cytotoxic agents against solid tumours and hematological malignancies |
| url | http://dx.doi.org/10.1155/1994/474259 |
| work_keys_str_mv | AT scottwadler newerclinicalstrategiesforcombininginterferonandcytotoxicagentsagainstsolidtumoursandhematologicalmalignancies |