Analysis of the influencing factors on serum reversal in HIV-exposed children

Analysis of the influencing factors on serum reversal in HIV-exposed children

Objective To study the factors influencing serum reversal in HIV-exposed children.Methods The general information, clinical data, and serum results of 49 cases of HIV-infected pregnant women and their children exposed to HIV were collected from the Shenzhen Third People's Hospital from January...

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Bibliographic Details
Main Authors: LI Xiaoling, WU Xiaodong, YUAN Dongmei, HUANG Ting, LIU Xiaoning, XIA Junxia, LI Shaqian, HUANG Haiying, HE Yun
Format: Article
Language:zho
Published: Editorial Office of New Medicine 2024-05-01
Series:Yixue xinzhi zazhi
Subjects:
hiv-infected pregnant women
hiv-exposed children
serum reversal
early infant diagnosis
mother-to-child transmission
nucleic acid test
influencing factors
Online Access:https://yxxz.whuznhmedj.com/futureApi/storage/attach/2406/dgJuqxGKZ5gdldftiMgc4Q8JCkmEDMR31BmiVDcB.pdf
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Summary:Objective To study the factors influencing serum reversal in HIV-exposed children.Methods The general information, clinical data, and serum results of 49 cases of HIV-infected pregnant women and their children exposed to HIV were collected from the Shenzhen Third People's Hospital from January 2019 to December 2021.Results  All 49 HIV-exposed children were tested negative for HIV nucleic acid at 48 h, 6 weeks, and 3 months of age. The serum reversal rates at 12, 18 and 21 months were 59.18%, 93.87% and 100%, respectively. Whether the serum of HIV-exposed children was reversed at 12 months of age was not related to the maternal delivery, anti-retroviral therapy initiation time, nucleic acid test results, CD4+T lymphocyte count (P>0.05). It was not related to children’s sex, gestational age, birth weight, and the type of blocking drug used (P>0.05).Conclusion No clear influencing factors were found for serum reversal in HIV-exposed 12-month-old children. The consistency between nucleic acid detection and final serum reversal was 100%. In order to exclude the possibility of HIV infection as soon as possible and reduce family concerns, three times of negative nucleic acid results before 3 months of age in HIV-exposed children may be considered as a substitute for serum reversal.
ISSN:1004-5511

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