Nuclear Alarmin Cytokines in Inflammation
Pathogen-associated molecular patterns (PAMPs) are some nonspecific and highly conserved molecular structures of exogenous specific microbial pathogens, whose products can be recognized by pattern recognition receptor (PRR) on innate immune cells and induce an inflammatory response. Under physiologi...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/7206451 |
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| _version_ | 1832547776460750848 |
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| author | Lili Jiang Yijia Shao Yao Tian Changsheng Ouyang Xiaohua Wang |
| author_facet | Lili Jiang Yijia Shao Yao Tian Changsheng Ouyang Xiaohua Wang |
| author_sort | Lili Jiang |
| collection | DOAJ |
| description | Pathogen-associated molecular patterns (PAMPs) are some nonspecific and highly conserved molecular structures of exogenous specific microbial pathogens, whose products can be recognized by pattern recognition receptor (PRR) on innate immune cells and induce an inflammatory response. Under physiological stress, activated or damaged cells might release some endogenous proteins that can also bind to PRR and cause a harmful aseptic inflammatory response. These endogenous proteins were named damage-associated molecular patterns (DAMPs) or alarmins. Indeed, alarmins can also play a beneficial role in the tissue repair in certain environments. Besides, some alarmin cytokines have been reported to have both nuclear and extracellular effects. This group of proteins includes high-mobility group box-1 protein (HMGB1), interleukin (IL)-33, IL-1α, IL-1F7b, and IL-16. In this article, we review the involvement of nuclear alarmins such as HMGB1, IL-33, and IL-1α under physiological state or stress state and suggest a novel activity of these molecules as central initiators in the development of sterile inflammation. |
| format | Article |
| id | doaj-art-50c81633fb5241c6a07095a9721ba311 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-50c81633fb5241c6a07095a9721ba3112025-02-03T06:43:30ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/72064517206451Nuclear Alarmin Cytokines in InflammationLili Jiang0Yijia Shao1Yao Tian2Changsheng Ouyang3Xiaohua Wang4Department of Rheumatology and Clinical Immunology, Jiangxi Provincial People’s Hospital Affiliated to Nanchang University, Nanchang, ChinaDepartment of Rheumatology and Clinical Immunology, Jiangxi Provincial People’s Hospital Affiliated to Nanchang University, Nanchang, ChinaDepartment of Rheumatology and Clinical Immunology, Jiangxi Provincial People’s Hospital Affiliated to Nanchang University, Nanchang, ChinaDepartment of Cardiology, Jiangxi Provincial People’s Hospital Affiliated to Nanchang University, Nanchang, ChinaGeriatric Medical Center, Jiangxi Provincial People’s Hospital Affiliated to Nanchang University, ChinaPathogen-associated molecular patterns (PAMPs) are some nonspecific and highly conserved molecular structures of exogenous specific microbial pathogens, whose products can be recognized by pattern recognition receptor (PRR) on innate immune cells and induce an inflammatory response. Under physiological stress, activated or damaged cells might release some endogenous proteins that can also bind to PRR and cause a harmful aseptic inflammatory response. These endogenous proteins were named damage-associated molecular patterns (DAMPs) or alarmins. Indeed, alarmins can also play a beneficial role in the tissue repair in certain environments. Besides, some alarmin cytokines have been reported to have both nuclear and extracellular effects. This group of proteins includes high-mobility group box-1 protein (HMGB1), interleukin (IL)-33, IL-1α, IL-1F7b, and IL-16. In this article, we review the involvement of nuclear alarmins such as HMGB1, IL-33, and IL-1α under physiological state or stress state and suggest a novel activity of these molecules as central initiators in the development of sterile inflammation.http://dx.doi.org/10.1155/2020/7206451 |
| spellingShingle | Lili Jiang Yijia Shao Yao Tian Changsheng Ouyang Xiaohua Wang Nuclear Alarmin Cytokines in Inflammation Journal of Immunology Research |
| title | Nuclear Alarmin Cytokines in Inflammation |
| title_full | Nuclear Alarmin Cytokines in Inflammation |
| title_fullStr | Nuclear Alarmin Cytokines in Inflammation |
| title_full_unstemmed | Nuclear Alarmin Cytokines in Inflammation |
| title_short | Nuclear Alarmin Cytokines in Inflammation |
| title_sort | nuclear alarmin cytokines in inflammation |
| url | http://dx.doi.org/10.1155/2020/7206451 |
| work_keys_str_mv | AT lilijiang nuclearalarmincytokinesininflammation AT yijiashao nuclearalarmincytokinesininflammation AT yaotian nuclearalarmincytokinesininflammation AT changshengouyang nuclearalarmincytokinesininflammation AT xiaohuawang nuclearalarmincytokinesininflammation |