Schiff bases and their possible therapeutic applications: A review
Schiff base (SB) represents a category of organic compounds in which a nitrogen atom with a double bond maintains its stereochemistry. The long history of Schiff base has been fascinating chemists to explore its new dimension by generating optimal analogs with their therapeutic effects to serve the...
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Elsevier
2025-01-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715624006374 |
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| author | Nidhi Siddharam Devendra Pratap Rao Amit Kumar Gautam Ashish Verma Yashveer Gautam |
| author_facet | Nidhi Siddharam Devendra Pratap Rao Amit Kumar Gautam Ashish Verma Yashveer Gautam |
| author_sort | Nidhi |
| collection | DOAJ |
| description | Schiff base (SB) represents a category of organic compounds in which a nitrogen atom with a double bond maintains its stereochemistry. The long history of Schiff base has been fascinating chemists to explore its new dimension by generating optimal analogs with their therapeutic effects to serve the humankind. Schiff base coupled with metals evolves as a new stable molecule with their therapeutic indication either as antifungal, antibacterial, anticancer or antiproliferative agents. Fusion of Schiff base with heterocyclic compounds like pyrazole or imidazole moieties conjointly crop different molecular entities with antifungal properties. Similarly, the amalgamation of Schiff base with benzene derivatives yields a new molecule with high antibacterial properties. However, further structural optimization may showcase other antimicrobial activities to prove this molecular entity as a potential druggable candidate. Apart from these, the well-known Schiff base anticancer and antiproliferative properties of this molecular entity are being explored. Schiff base, however, is suspected of causing cancer and can cause severe eye discomfort. |
| format | Article |
| id | doaj-art-50c762c4d1954d2fb67293a71415eae3 |
| institution | Kabale University |
| issn | 2211-7156 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj-art-50c762c4d1954d2fb67293a71415eae32025-01-29T05:00:38ZengElsevierResults in Chemistry2211-71562025-01-0113101941Schiff bases and their possible therapeutic applications: A review Nidhi0 Siddharam1Devendra Pratap Rao2Amit Kumar Gautam3Ashish Verma4Yashveer Gautam5Department of Chemistry, Coordination Chemistry Laboratory, Dayanand Anglo-Vedic (PG) College, Kanpur 208001, U.P., IndiaDepartment of Chemistry, Coordination Chemistry Laboratory, Dayanand Anglo-Vedic (PG) College, Kanpur 208001, U.P., IndiaDepartment of Chemistry, Coordination Chemistry Laboratory, Dayanand Anglo-Vedic (PG) College, Kanpur 208001, U.P., India; Corresponding author.Department of Chemistry, Coordination Chemistry Laboratory, Dayanand Anglo-Vedic (PG) College, Kanpur 208001, U.P., IndiaDepartment of Chemistry, Coordination Chemistry Laboratory, Dayanand Anglo-Vedic (PG) College, Kanpur 208001, U.P., IndiaDepartment of Chemistry, Pandit Prithi Nath (PG) College, Kanpur 208001, U.P., IndiaSchiff base (SB) represents a category of organic compounds in which a nitrogen atom with a double bond maintains its stereochemistry. The long history of Schiff base has been fascinating chemists to explore its new dimension by generating optimal analogs with their therapeutic effects to serve the humankind. Schiff base coupled with metals evolves as a new stable molecule with their therapeutic indication either as antifungal, antibacterial, anticancer or antiproliferative agents. Fusion of Schiff base with heterocyclic compounds like pyrazole or imidazole moieties conjointly crop different molecular entities with antifungal properties. Similarly, the amalgamation of Schiff base with benzene derivatives yields a new molecule with high antibacterial properties. However, further structural optimization may showcase other antimicrobial activities to prove this molecular entity as a potential druggable candidate. Apart from these, the well-known Schiff base anticancer and antiproliferative properties of this molecular entity are being explored. Schiff base, however, is suspected of causing cancer and can cause severe eye discomfort.http://www.sciencedirect.com/science/article/pii/S2211715624006374Schiff baseMedical conditionMicroorganismBroad spectrumMolecular entity |
| spellingShingle | Nidhi Siddharam Devendra Pratap Rao Amit Kumar Gautam Ashish Verma Yashveer Gautam Schiff bases and their possible therapeutic applications: A review Results in Chemistry Schiff base Medical condition Microorganism Broad spectrum Molecular entity |
| title | Schiff bases and their possible therapeutic applications: A review |
| title_full | Schiff bases and their possible therapeutic applications: A review |
| title_fullStr | Schiff bases and their possible therapeutic applications: A review |
| title_full_unstemmed | Schiff bases and their possible therapeutic applications: A review |
| title_short | Schiff bases and their possible therapeutic applications: A review |
| title_sort | schiff bases and their possible therapeutic applications a review |
| topic | Schiff base Medical condition Microorganism Broad spectrum Molecular entity |
| url | http://www.sciencedirect.com/science/article/pii/S2211715624006374 |
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