Clinical observations of patients with metastatic castration-resistant prostate cancer living in the Tambov region
Treatment of patients with metastatic castration-resistant prostate cancer in clinical practice is a vital necessity and a challenging task since the causes of castration resistance are not fully understood. Adherence to treatment regimens in accordance with the National Clinical Guidelines allows t...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
QUASAR, LLC
2023-09-01
|
| Series: | Исследования и практика в медицине |
| Subjects: | |
| Online Access: | https://www.rpmj.ru/rpmj/article/view/921 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832568635463303168 |
|---|---|
| author | P. G. Berezin V. V. Milovanov A. A. Ivannikov V. A. Kuleshkov K. M. Nyushko |
| author_facet | P. G. Berezin V. V. Milovanov A. A. Ivannikov V. A. Kuleshkov K. M. Nyushko |
| author_sort | P. G. Berezin |
| collection | DOAJ |
| description | Treatment of patients with metastatic castration-resistant prostate cancer in clinical practice is a vital necessity and a challenging task since the causes of castration resistance are not fully understood. Adherence to treatment regimens in accordance with the National Clinical Guidelines allows to achieve an increase in both overall survival and progression-free survival, as well as to reduce the mortality rate in this category of patients. Administration of 1st-line treatment regimens stabilizes the disease in the majority of pancreatic cancer patients; in some cases, the disease becomes aggressive, distant metastases appear, most oſten in bones, lymph nodes, and internal organs, as demonstrated by three clinical observations presented in this article. The administration of enzalutamide (in 2 cases) and abiraterone acetate (in 1 case) at the stage of resistance to castration therapy allowed to obtain a complete “response” from visceral lesions, stabilise bone metastatic foci and increase the life expectancy of patients. |
| format | Article |
| id | doaj-art-50bcc9ec3d2843cc9a26e126588c3f6a |
| institution | Kabale University |
| issn | 2410-1893 |
| language | Russian |
| publishDate | 2023-09-01 |
| publisher | QUASAR, LLC |
| record_format | Article |
| series | Исследования и практика в медицине |
| spelling | doaj-art-50bcc9ec3d2843cc9a26e126588c3f6a2025-02-03T00:57:40ZrusQUASAR, LLCИсследования и практика в медицине2410-18932023-09-01103869610.17709/410-1893-2023-10-3-8517Clinical observations of patients with metastatic castration-resistant prostate cancer living in the Tambov regionP. G. Berezin0V. V. Milovanov1A. A. Ivannikov2V. A. Kuleshkov3K. M. Nyushko4Tambov Regional Oncological Clinical DispensaryTambov Regional Oncological Clinical DispensaryTambov Regional Oncological Clinical DispensaryS. S. Bryukhonenko City HospitalLopatkin Scientific Research Institute of Urology and Interventional Radiology – Branch of the National Medical Research Radiologiсal CenterTreatment of patients with metastatic castration-resistant prostate cancer in clinical practice is a vital necessity and a challenging task since the causes of castration resistance are not fully understood. Adherence to treatment regimens in accordance with the National Clinical Guidelines allows to achieve an increase in both overall survival and progression-free survival, as well as to reduce the mortality rate in this category of patients. Administration of 1st-line treatment regimens stabilizes the disease in the majority of pancreatic cancer patients; in some cases, the disease becomes aggressive, distant metastases appear, most oſten in bones, lymph nodes, and internal organs, as demonstrated by three clinical observations presented in this article. The administration of enzalutamide (in 2 cases) and abiraterone acetate (in 1 case) at the stage of resistance to castration therapy allowed to obtain a complete “response” from visceral lesions, stabilise bone metastatic foci and increase the life expectancy of patients.https://www.rpmj.ru/rpmj/article/view/921metastatic castration-resistant prostate cancercombined treatment regimenslife expectancy |
| spellingShingle | P. G. Berezin V. V. Milovanov A. A. Ivannikov V. A. Kuleshkov K. M. Nyushko Clinical observations of patients with metastatic castration-resistant prostate cancer living in the Tambov region Исследования и практика в медицине metastatic castration-resistant prostate cancer combined treatment regimens life expectancy |
| title | Clinical observations of patients with metastatic castration-resistant prostate cancer living in the Tambov region |
| title_full | Clinical observations of patients with metastatic castration-resistant prostate cancer living in the Tambov region |
| title_fullStr | Clinical observations of patients with metastatic castration-resistant prostate cancer living in the Tambov region |
| title_full_unstemmed | Clinical observations of patients with metastatic castration-resistant prostate cancer living in the Tambov region |
| title_short | Clinical observations of patients with metastatic castration-resistant prostate cancer living in the Tambov region |
| title_sort | clinical observations of patients with metastatic castration resistant prostate cancer living in the tambov region |
| topic | metastatic castration-resistant prostate cancer combined treatment regimens life expectancy |
| url | https://www.rpmj.ru/rpmj/article/view/921 |
| work_keys_str_mv | AT pgberezin clinicalobservationsofpatientswithmetastaticcastrationresistantprostatecancerlivinginthetambovregion AT vvmilovanov clinicalobservationsofpatientswithmetastaticcastrationresistantprostatecancerlivinginthetambovregion AT aaivannikov clinicalobservationsofpatientswithmetastaticcastrationresistantprostatecancerlivinginthetambovregion AT vakuleshkov clinicalobservationsofpatientswithmetastaticcastrationresistantprostatecancerlivinginthetambovregion AT kmnyushko clinicalobservationsofpatientswithmetastaticcastrationresistantprostatecancerlivinginthetambovregion |