Plastin Family of Actin-Bundling Proteins: Its Functions in Leukocytes, Neurons, Intestines, and Cancer
Sophisticated regulation of the actin cytoskeleton by a variety of actin-binding proteins is essential for eukaryotic cells to perform their diverse functions. The plastin (also know, as fimbrin) protein family belongs to actin-bundling proteins, and the protein family is evolutionarily conserved an...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2012/213492 |
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| author | Hiroto Shinomiya |
| author_facet | Hiroto Shinomiya |
| author_sort | Hiroto Shinomiya |
| collection | DOAJ |
| description | Sophisticated regulation of the actin cytoskeleton by a variety of actin-binding proteins is essential for eukaryotic cells to perform their diverse functions. The plastin (also know, as fimbrin) protein family belongs to actin-bundling proteins, and the protein family is evolutionarily conserved and expressed in yeast, plant, and animal cells. Plastins are characterized by EF-hand Ca2+-binding domains and actin-binding domains and can cross-link actin filaments into higher-order assemblies like bundles. Three isoforms have been identified in mammals. T-plastin is expressed in cells from solid tissues, such as neurons in the brain. I-plastin expression is restricted to intestine and kidney; the isoform plays a vital role in the function of absorptive epithelia in these organs. L-plastin is expressed in hematopoietic cell lineages and in many types of cancer cells; the isoform is thus considered to be a useful biomarker for cancer. |
| format | Article |
| id | doaj-art-50b8ccfa5b884098be311f6b4c1f3583 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-50b8ccfa5b884098be311f6b4c1f35832025-02-03T01:31:00ZengWileyInternational Journal of Cell Biology1687-88761687-88842012-01-01201210.1155/2012/213492213492Plastin Family of Actin-Bundling Proteins: Its Functions in Leukocytes, Neurons, Intestines, and CancerHiroto Shinomiya0Department of Immunology and Host Defenses, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, JapanSophisticated regulation of the actin cytoskeleton by a variety of actin-binding proteins is essential for eukaryotic cells to perform their diverse functions. The plastin (also know, as fimbrin) protein family belongs to actin-bundling proteins, and the protein family is evolutionarily conserved and expressed in yeast, plant, and animal cells. Plastins are characterized by EF-hand Ca2+-binding domains and actin-binding domains and can cross-link actin filaments into higher-order assemblies like bundles. Three isoforms have been identified in mammals. T-plastin is expressed in cells from solid tissues, such as neurons in the brain. I-plastin expression is restricted to intestine and kidney; the isoform plays a vital role in the function of absorptive epithelia in these organs. L-plastin is expressed in hematopoietic cell lineages and in many types of cancer cells; the isoform is thus considered to be a useful biomarker for cancer.http://dx.doi.org/10.1155/2012/213492 |
| spellingShingle | Hiroto Shinomiya Plastin Family of Actin-Bundling Proteins: Its Functions in Leukocytes, Neurons, Intestines, and Cancer International Journal of Cell Biology |
| title | Plastin Family of Actin-Bundling Proteins: Its Functions in
Leukocytes, Neurons, Intestines, and Cancer |
| title_full | Plastin Family of Actin-Bundling Proteins: Its Functions in
Leukocytes, Neurons, Intestines, and Cancer |
| title_fullStr | Plastin Family of Actin-Bundling Proteins: Its Functions in
Leukocytes, Neurons, Intestines, and Cancer |
| title_full_unstemmed | Plastin Family of Actin-Bundling Proteins: Its Functions in
Leukocytes, Neurons, Intestines, and Cancer |
| title_short | Plastin Family of Actin-Bundling Proteins: Its Functions in
Leukocytes, Neurons, Intestines, and Cancer |
| title_sort | plastin family of actin bundling proteins its functions in leukocytes neurons intestines and cancer |
| url | http://dx.doi.org/10.1155/2012/213492 |
| work_keys_str_mv | AT hirotoshinomiya plastinfamilyofactinbundlingproteinsitsfunctionsinleukocytesneuronsintestinesandcancer |