Minimizing Hemodialysis Catheter Dysfunction: An Ounce of Prevention
The maintenance of tunneled catheter (TC) patency is critical for the provision of adequate hemodialysis in patients who are TC-dependent. TC dysfunction results in the need for costly and inconvenient interventions, and reduced quality of life. Since the introduction of TCs in the late 1980s, hepar...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2012/170857 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832557017251708928 |
|---|---|
| author | Timmy Lee Charmaine Lok Miguel Vazquez Louise Moist Ivan Maya Michele Mokrzycki |
| author_facet | Timmy Lee Charmaine Lok Miguel Vazquez Louise Moist Ivan Maya Michele Mokrzycki |
| author_sort | Timmy Lee |
| collection | DOAJ |
| description | The maintenance of tunneled catheter (TC) patency is critical for the provision of adequate hemodialysis in patients who are TC-dependent. TC dysfunction results in the need for costly and inconvenient interventions, and reduced quality of life. Since the introduction of TCs in the late 1980s, heparin catheter lock has been the standard prophylactic regimen for the prevention of TC dysfunction. More recently, alternative catheter locking agents have emerged, and in some cases have shown to be superior to heparin lock with respect to improving TC patency and reducing TC-associated infections. These include citrate, tissue plasminogen activator, and a novel agent containing sodium citrate, methylene blue, methylparaben, and propylparaben. In addition, prophylaxis using oral anticoagulants/antiplatelet agents, including warfarin, aspirin, ticlodipine, as well as the use of modified heparin-coated catheters have also been studied for the prevention of TC dysfunction with variable results. The use of oral anticoagulants and/or antiplatelet agents as primary or secondary prevention of TC dysfunction must be weighed against their potential adverse effects, and should be individualized for each patient. |
| format | Article |
| id | doaj-art-50b78cff36374aeeb2c35a00fe29345d |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-50b78cff36374aeeb2c35a00fe29345d2025-02-03T05:43:49ZengWileyInternational Journal of Nephrology2090-214X2090-21582012-01-01201210.1155/2012/170857170857Minimizing Hemodialysis Catheter Dysfunction: An Ounce of PreventionTimmy Lee0Charmaine Lok1Miguel Vazquez2Louise Moist3Ivan Maya4Michele Mokrzycki5University of Cincinnati, Cincinnati, OH 45267-0585, USAFaculty of Medicine, University of Toronto, University Health Network-Toronto General Hospital, Toronto, ON, M5G 2C4, CanadaUniversity of Texas Southwestern Medical Center, Dallas, TX 75390-8856, USADepartment of Epidemiology and Biostatistics, University of Western Ontario, London, ON, N6A 5W9, CanadaNephrology Associates of Central Florida, Lake Mary, FL 32746, USAAlbert Einstein College of Medicine, Bronx, NY 10467, USAThe maintenance of tunneled catheter (TC) patency is critical for the provision of adequate hemodialysis in patients who are TC-dependent. TC dysfunction results in the need for costly and inconvenient interventions, and reduced quality of life. Since the introduction of TCs in the late 1980s, heparin catheter lock has been the standard prophylactic regimen for the prevention of TC dysfunction. More recently, alternative catheter locking agents have emerged, and in some cases have shown to be superior to heparin lock with respect to improving TC patency and reducing TC-associated infections. These include citrate, tissue plasminogen activator, and a novel agent containing sodium citrate, methylene blue, methylparaben, and propylparaben. In addition, prophylaxis using oral anticoagulants/antiplatelet agents, including warfarin, aspirin, ticlodipine, as well as the use of modified heparin-coated catheters have also been studied for the prevention of TC dysfunction with variable results. The use of oral anticoagulants and/or antiplatelet agents as primary or secondary prevention of TC dysfunction must be weighed against their potential adverse effects, and should be individualized for each patient.http://dx.doi.org/10.1155/2012/170857 |
| spellingShingle | Timmy Lee Charmaine Lok Miguel Vazquez Louise Moist Ivan Maya Michele Mokrzycki Minimizing Hemodialysis Catheter Dysfunction: An Ounce of Prevention International Journal of Nephrology |
| title | Minimizing Hemodialysis Catheter Dysfunction: An Ounce of Prevention |
| title_full | Minimizing Hemodialysis Catheter Dysfunction: An Ounce of Prevention |
| title_fullStr | Minimizing Hemodialysis Catheter Dysfunction: An Ounce of Prevention |
| title_full_unstemmed | Minimizing Hemodialysis Catheter Dysfunction: An Ounce of Prevention |
| title_short | Minimizing Hemodialysis Catheter Dysfunction: An Ounce of Prevention |
| title_sort | minimizing hemodialysis catheter dysfunction an ounce of prevention |
| url | http://dx.doi.org/10.1155/2012/170857 |
| work_keys_str_mv | AT timmylee minimizinghemodialysiscatheterdysfunctionanounceofprevention AT charmainelok minimizinghemodialysiscatheterdysfunctionanounceofprevention AT miguelvazquez minimizinghemodialysiscatheterdysfunctionanounceofprevention AT louisemoist minimizinghemodialysiscatheterdysfunctionanounceofprevention AT ivanmaya minimizinghemodialysiscatheterdysfunctionanounceofprevention AT michelemokrzycki minimizinghemodialysiscatheterdysfunctionanounceofprevention |