Anticancer Activity of Ferulic Acid-Inorganic Nanohybrids Synthesized via Two Different Hybridization Routes, Reconstruction and Exfoliation-Reassembly
We have successfully prepared nanohybrids of biofunctional ferulic acid and layered double hydroxide nanomaterials through reconstruction and exfoliation-reassembly routes. From X-ray diffraction and infrared spectroscopy, both nanohybrids were determined to incorporate ferulic acid molecules in ani...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/421967 |
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| author | Hyoung-Jun Kim Kitae Ryu Joo-Hee Kang Ae-Jin Choi Tae-il Kim Jae-Min Oh |
| author_facet | Hyoung-Jun Kim Kitae Ryu Joo-Hee Kang Ae-Jin Choi Tae-il Kim Jae-Min Oh |
| author_sort | Hyoung-Jun Kim |
| collection | DOAJ |
| description | We have successfully prepared nanohybrids of biofunctional ferulic acid and layered double hydroxide nanomaterials through reconstruction and exfoliation-reassembly routes. From X-ray diffraction and infrared spectroscopy, both nanohybrids were determined to incorporate ferulic acid molecules in anionic form. Micrsocopic results showed that the nanohybrids had average particle size of 150 nm with plate-like morphology. As the two nanohybridization routes involved crystal disorder and random stacking of layers, the nanohybrids showed slight alteration in z-axis crystallinity and particle size. The zeta potential values of pristine and nanohybrids in deionized water were determined to be positive, while those in cell culture media shifted to negative values. According to the in vitro anticancer activity test on human cervical cancer HeLa cells, it was revealed that nanohybrids showed twice anticancer activity compared with ferulic acid itself. Therefore we could conclude that the nanohybrids of ferulic acid and layered double hydroxide had cellular delivery property of intercalated molecules on cancer cell lines. |
| format | Article |
| id | doaj-art-50b476a5f0584f2dab3a8e4c3e6bc559 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-50b476a5f0584f2dab3a8e4c3e6bc5592025-02-03T06:42:01ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/421967421967Anticancer Activity of Ferulic Acid-Inorganic Nanohybrids Synthesized via Two Different Hybridization Routes, Reconstruction and Exfoliation-ReassemblyHyoung-Jun Kim0Kitae Ryu1Joo-Hee Kang2Ae-Jin Choi3Tae-il Kim4Jae-Min Oh5Department of Chemistry and Medical Chemistry, College of Science and Technology, Yonsei University, Wonju, Gangwon-do 220-710, Republic of KoreaDepartment of Biosystems and Biomaterials Science and Engineering, College of Agriculture and Life Sciences, Seoul National University, Seoul 151-921, Republic of KoreaR&I Korea, GBU SC, Solvay, Industry-University Cooperation Building, Ewha Womans University, 150 Bukahyun-ro, Seodaemun-gu, Seoul 120-750, Republic of KoreaNational Institute of Horticultural & Herbal Science (NIHHS) of RDA, Eumseong-gun, Chungcheongbuk-do 369-873, Republic of KoreaDepartment of Biosystems and Biomaterials Science and Engineering, College of Agriculture and Life Sciences, Seoul National University, Seoul 151-921, Republic of KoreaDepartment of Chemistry and Medical Chemistry, College of Science and Technology, Yonsei University, Wonju, Gangwon-do 220-710, Republic of KoreaWe have successfully prepared nanohybrids of biofunctional ferulic acid and layered double hydroxide nanomaterials through reconstruction and exfoliation-reassembly routes. From X-ray diffraction and infrared spectroscopy, both nanohybrids were determined to incorporate ferulic acid molecules in anionic form. Micrsocopic results showed that the nanohybrids had average particle size of 150 nm with plate-like morphology. As the two nanohybridization routes involved crystal disorder and random stacking of layers, the nanohybrids showed slight alteration in z-axis crystallinity and particle size. The zeta potential values of pristine and nanohybrids in deionized water were determined to be positive, while those in cell culture media shifted to negative values. According to the in vitro anticancer activity test on human cervical cancer HeLa cells, it was revealed that nanohybrids showed twice anticancer activity compared with ferulic acid itself. Therefore we could conclude that the nanohybrids of ferulic acid and layered double hydroxide had cellular delivery property of intercalated molecules on cancer cell lines.http://dx.doi.org/10.1155/2013/421967 |
| spellingShingle | Hyoung-Jun Kim Kitae Ryu Joo-Hee Kang Ae-Jin Choi Tae-il Kim Jae-Min Oh Anticancer Activity of Ferulic Acid-Inorganic Nanohybrids Synthesized via Two Different Hybridization Routes, Reconstruction and Exfoliation-Reassembly The Scientific World Journal |
| title | Anticancer Activity of Ferulic Acid-Inorganic Nanohybrids Synthesized via Two Different Hybridization Routes, Reconstruction and Exfoliation-Reassembly |
| title_full | Anticancer Activity of Ferulic Acid-Inorganic Nanohybrids Synthesized via Two Different Hybridization Routes, Reconstruction and Exfoliation-Reassembly |
| title_fullStr | Anticancer Activity of Ferulic Acid-Inorganic Nanohybrids Synthesized via Two Different Hybridization Routes, Reconstruction and Exfoliation-Reassembly |
| title_full_unstemmed | Anticancer Activity of Ferulic Acid-Inorganic Nanohybrids Synthesized via Two Different Hybridization Routes, Reconstruction and Exfoliation-Reassembly |
| title_short | Anticancer Activity of Ferulic Acid-Inorganic Nanohybrids Synthesized via Two Different Hybridization Routes, Reconstruction and Exfoliation-Reassembly |
| title_sort | anticancer activity of ferulic acid inorganic nanohybrids synthesized via two different hybridization routes reconstruction and exfoliation reassembly |
| url | http://dx.doi.org/10.1155/2013/421967 |
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