Mycobacterium intracellulare Infection Mimicking Progression of Scleroderma
This case report describes a patient with scleroderma who developed Mycobacterium intracellulare infection, which for more than a year mimicked worsening of her connective tissue disorder. The patient was diagnosed with scleroderma based on puffy fingers that developed into sclerodactyly, abnormal n...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2017/4029271 |
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| author | Simon Krabbe Merete Engelhart Sören Thybo Søren Jacobsen |
| author_facet | Simon Krabbe Merete Engelhart Sören Thybo Søren Jacobsen |
| author_sort | Simon Krabbe |
| collection | DOAJ |
| description | This case report describes a patient with scleroderma who developed Mycobacterium intracellulare infection, which for more than a year mimicked worsening of her connective tissue disorder. The patient was diagnosed with scleroderma based on puffy fingers that developed into sclerodactyly, abnormal nail fold capillaries, interstitial lung disease, Raynaud’s phenomenon, esophageal dysmotility, and positivity for rheumatoid factor and anti-SSA antibodies. She developed massive inflammatory changes of the cutis, the subcutis, and the muscle fasciae of the right leg, that after several failed attempts of immunosuppressive treatments were found to be caused by Mycobacterium intracellulare. While she was receiving high-dose prednisolone, as worsening of her connective tissue disease was suspected to be the cause of the inflammatory changes, she had Listeria monocytogenes meningitis and was hospitalized for several weeks, but she recovered from this without sequelae. After Mycobacterium intracellulare infection was diagnosed, she was treated with clarithromycin and rifampicin. Her skin manifestations, arthralgias, and fatigue improved considerably, and the wounds of the right leg healed, unfortunately with significant scarring. Immunodeficiency testing was unremarkable. In summary, an infection with Mycobacterium intracellulare was mistaken for an unusually severe progression of scleroderma. |
| format | Article |
| id | doaj-art-50a9c0775ede40dd873d897b12a2f391 |
| institution | Kabale University |
| issn | 2090-6889 2090-6897 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-50a9c0775ede40dd873d897b12a2f3912025-02-03T01:29:02ZengWileyCase Reports in Rheumatology2090-68892090-68972017-01-01201710.1155/2017/40292714029271Mycobacterium intracellulare Infection Mimicking Progression of SclerodermaSimon Krabbe0Merete Engelhart1Sören Thybo2Søren Jacobsen3Center for Rheumatology and Spine Diseases, Rigshospitalet, 2600 Glostrup, DenmarkCenter for Rheumatology and Spine Diseases, Gentofte Hospital, 2900 Hellerup, DenmarkDepartment of Infectious Diseases, Rigshospitalet, 2100 Copenhagen, DenmarkCenter for Rheumatology and Spine Diseases, Rigshospitalet, 2100 Copenhagen, DenmarkThis case report describes a patient with scleroderma who developed Mycobacterium intracellulare infection, which for more than a year mimicked worsening of her connective tissue disorder. The patient was diagnosed with scleroderma based on puffy fingers that developed into sclerodactyly, abnormal nail fold capillaries, interstitial lung disease, Raynaud’s phenomenon, esophageal dysmotility, and positivity for rheumatoid factor and anti-SSA antibodies. She developed massive inflammatory changes of the cutis, the subcutis, and the muscle fasciae of the right leg, that after several failed attempts of immunosuppressive treatments were found to be caused by Mycobacterium intracellulare. While she was receiving high-dose prednisolone, as worsening of her connective tissue disease was suspected to be the cause of the inflammatory changes, she had Listeria monocytogenes meningitis and was hospitalized for several weeks, but she recovered from this without sequelae. After Mycobacterium intracellulare infection was diagnosed, she was treated with clarithromycin and rifampicin. Her skin manifestations, arthralgias, and fatigue improved considerably, and the wounds of the right leg healed, unfortunately with significant scarring. Immunodeficiency testing was unremarkable. In summary, an infection with Mycobacterium intracellulare was mistaken for an unusually severe progression of scleroderma.http://dx.doi.org/10.1155/2017/4029271 |
| spellingShingle | Simon Krabbe Merete Engelhart Sören Thybo Søren Jacobsen Mycobacterium intracellulare Infection Mimicking Progression of Scleroderma Case Reports in Rheumatology |
| title | Mycobacterium intracellulare Infection Mimicking Progression of Scleroderma |
| title_full | Mycobacterium intracellulare Infection Mimicking Progression of Scleroderma |
| title_fullStr | Mycobacterium intracellulare Infection Mimicking Progression of Scleroderma |
| title_full_unstemmed | Mycobacterium intracellulare Infection Mimicking Progression of Scleroderma |
| title_short | Mycobacterium intracellulare Infection Mimicking Progression of Scleroderma |
| title_sort | mycobacterium intracellulare infection mimicking progression of scleroderma |
| url | http://dx.doi.org/10.1155/2017/4029271 |
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