Dendritic Cells and Their Role in Cardiovascular Diseases: A View on Human Studies
The antigen-presenting dendritic cells (DCs) are key to the immunological response, with different functions ascribed ranging from cellular immune activation to induction of tolerance. Such immunological responses are involved in the pathophysiological mechanisms of cardiovascular diseases, with DCs...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/5946807 |
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| _version_ | 1832552223457935360 |
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| author | Maja-Theresa Dieterlen Katja John Hermann Reichenspurner Friedrich W. Mohr Markus J. Barten |
| author_facet | Maja-Theresa Dieterlen Katja John Hermann Reichenspurner Friedrich W. Mohr Markus J. Barten |
| author_sort | Maja-Theresa Dieterlen |
| collection | DOAJ |
| description | The antigen-presenting dendritic cells (DCs) are key to the immunological response, with different functions ascribed ranging from cellular immune activation to induction of tolerance. Such immunological responses are involved in the pathophysiological mechanisms of cardiovascular diseases, with DCs shown to play a role in atherosclerosis, hypertension, and heart failure and most notably following heart transplantation. A better understanding of the interplay between the immune system and cardiovascular diseases will therefore be critical for developing novel therapeutic treatments as well as innovative monitoring tools for disease progression. As such, the present review will provide an overview of DCs involvement in the pathophysiology of cardiovascular diseases and how targeting these cells may have beneficial effects for the prognosis of patients. |
| format | Article |
| id | doaj-art-50a26c39306a429d97e01499aeb05a25 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-50a26c39306a429d97e01499aeb05a252025-02-03T05:59:13ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/59468075946807Dendritic Cells and Their Role in Cardiovascular Diseases: A View on Human StudiesMaja-Theresa Dieterlen0Katja John1Hermann Reichenspurner2Friedrich W. Mohr3Markus J. Barten4Department of Cardiac Surgery, Heart Center, Helios Clinic, University Hospital Leipzig, 04289 Leipzig, GermanyDepartment of Cardiac Surgery, Heart Center, Helios Clinic, University Hospital Leipzig, 04289 Leipzig, GermanyDepartment of Cardiovascular Surgery, University Heart Center Hamburg, 20246 Hamburg, GermanyDepartment of Cardiac Surgery, Heart Center, Helios Clinic, University Hospital Leipzig, 04289 Leipzig, GermanyDepartment of Cardiovascular Surgery, University Heart Center Hamburg, 20246 Hamburg, GermanyThe antigen-presenting dendritic cells (DCs) are key to the immunological response, with different functions ascribed ranging from cellular immune activation to induction of tolerance. Such immunological responses are involved in the pathophysiological mechanisms of cardiovascular diseases, with DCs shown to play a role in atherosclerosis, hypertension, and heart failure and most notably following heart transplantation. A better understanding of the interplay between the immune system and cardiovascular diseases will therefore be critical for developing novel therapeutic treatments as well as innovative monitoring tools for disease progression. As such, the present review will provide an overview of DCs involvement in the pathophysiology of cardiovascular diseases and how targeting these cells may have beneficial effects for the prognosis of patients.http://dx.doi.org/10.1155/2016/5946807 |
| spellingShingle | Maja-Theresa Dieterlen Katja John Hermann Reichenspurner Friedrich W. Mohr Markus J. Barten Dendritic Cells and Their Role in Cardiovascular Diseases: A View on Human Studies Journal of Immunology Research |
| title | Dendritic Cells and Their Role in Cardiovascular Diseases: A View on Human Studies |
| title_full | Dendritic Cells and Their Role in Cardiovascular Diseases: A View on Human Studies |
| title_fullStr | Dendritic Cells and Their Role in Cardiovascular Diseases: A View on Human Studies |
| title_full_unstemmed | Dendritic Cells and Their Role in Cardiovascular Diseases: A View on Human Studies |
| title_short | Dendritic Cells and Their Role in Cardiovascular Diseases: A View on Human Studies |
| title_sort | dendritic cells and their role in cardiovascular diseases a view on human studies |
| url | http://dx.doi.org/10.1155/2016/5946807 |
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