Case report: The value of early application of mNGS technology in the diagnosis and treatment of severe Legionnaires’ disease: reports of two cases with different outcomes
BackgroundLegionnaires’ disease has a high clinical mortality rate, and early diagnosis and treatment are critical. Increasing evidence shows that metagenomic next-generation sequencing (mNGS) has excellent potential for the early identification of pathogens. To help clinicians better recognize Legi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1501192/full |
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| author | Jianqing Fang Zhe Wang Yu Shen Xuenong Wu Hao Fang Xiaokui Sun Ting Yu Qingqing Zhang |
| author_facet | Jianqing Fang Zhe Wang Yu Shen Xuenong Wu Hao Fang Xiaokui Sun Ting Yu Qingqing Zhang |
| author_sort | Jianqing Fang |
| collection | DOAJ |
| description | BackgroundLegionnaires’ disease has a high clinical mortality rate, and early diagnosis and treatment are critical. Increasing evidence shows that metagenomic next-generation sequencing (mNGS) has excellent potential for the early identification of pathogens. To help clinicians better recognize Legionnaires’ disease in its early stage and to illustrate the diagnostic value of mNGS technology, we reviewed and summarized two cases of severe Legionnaires’ disease.Methods and analysisWe selected two patients with severe Legionnaires’ disease who were admitted to our department in recent years. We discuss experience with them and the shortcomings in their treatment by summarizing their medical history, disease evolution, tests, and diagnostic and therapeutic processes.ResultsIn both patients, the diagnosis of Legionnaires’ disease was confirmed through analysis of the bronchoalveolar lavage fluid (BALF). The middle-aged male patient was cured and discharged due to early detection and diagnosis. The elderly immunocompromised patient died due to a delay in diagnosis.ConclusionThis study highlights the importance of the early recognition and diagnosis of severe Legionnaires’ disease and the advantages of mNGS in identifying the pathogen. |
| format | Article |
| id | doaj-art-50a0f941725542b881e1b710e2bc8ea3 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-50a0f941725542b881e1b710e2bc8ea32025-02-05T07:32:30ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-02-011210.3389/fmed.2025.15011921501192Case report: The value of early application of mNGS technology in the diagnosis and treatment of severe Legionnaires’ disease: reports of two cases with different outcomesJianqing Fang0Zhe Wang1Yu Shen2Xuenong Wu3Hao Fang4Xiaokui Sun5Ting Yu6Qingqing Zhang7Department of Respiratory and Critical Care Medicine, Hangzhou Linping Hospital of Traditional Chinese Medicine, Hangzhou, ChinaDepartment of Respiratory and Critical Care Medicine, Hangzhou Linping Hospital of Traditional Chinese Medicine, Hangzhou, ChinaDepartment of Ultrasound Medicine, Hangzhou Linping Hospital of Traditional Chinese Medicine, Hangzhou, ChinaDepartment of Respiratory and Critical Care Medicine, Hangzhou Linping Hospital of Traditional Chinese Medicine, Hangzhou, ChinaDepartment of Intensive Care Medicine, Hangzhou Linping Hospital of Traditional Chinese Medicine, Hangzhou, ChinaDepartment of Respiratory and Critical Care Medicine, Hangzhou Linping Hospital of Traditional Chinese Medicine, Hangzhou, ChinaDepartment of Respiratory and Critical Care Medicine, Hangzhou Linping Hospital of Traditional Chinese Medicine, Hangzhou, ChinaDepartment of Respiratory and Critical Care Medicine, Hangzhou Linping Hospital of Traditional Chinese Medicine, Hangzhou, ChinaBackgroundLegionnaires’ disease has a high clinical mortality rate, and early diagnosis and treatment are critical. Increasing evidence shows that metagenomic next-generation sequencing (mNGS) has excellent potential for the early identification of pathogens. To help clinicians better recognize Legionnaires’ disease in its early stage and to illustrate the diagnostic value of mNGS technology, we reviewed and summarized two cases of severe Legionnaires’ disease.Methods and analysisWe selected two patients with severe Legionnaires’ disease who were admitted to our department in recent years. We discuss experience with them and the shortcomings in their treatment by summarizing their medical history, disease evolution, tests, and diagnostic and therapeutic processes.ResultsIn both patients, the diagnosis of Legionnaires’ disease was confirmed through analysis of the bronchoalveolar lavage fluid (BALF). The middle-aged male patient was cured and discharged due to early detection and diagnosis. The elderly immunocompromised patient died due to a delay in diagnosis.ConclusionThis study highlights the importance of the early recognition and diagnosis of severe Legionnaires’ disease and the advantages of mNGS in identifying the pathogen.https://www.frontiersin.org/articles/10.3389/fmed.2025.1501192/fulllegionellosisLegionnaires’ diseasecase reportsevere community-acquired pneumoniasevere hospital-acquired pneumonia |
| spellingShingle | Jianqing Fang Zhe Wang Yu Shen Xuenong Wu Hao Fang Xiaokui Sun Ting Yu Qingqing Zhang Case report: The value of early application of mNGS technology in the diagnosis and treatment of severe Legionnaires’ disease: reports of two cases with different outcomes Frontiers in Medicine legionellosis Legionnaires’ disease case report severe community-acquired pneumonia severe hospital-acquired pneumonia |
| title | Case report: The value of early application of mNGS technology in the diagnosis and treatment of severe Legionnaires’ disease: reports of two cases with different outcomes |
| title_full | Case report: The value of early application of mNGS technology in the diagnosis and treatment of severe Legionnaires’ disease: reports of two cases with different outcomes |
| title_fullStr | Case report: The value of early application of mNGS technology in the diagnosis and treatment of severe Legionnaires’ disease: reports of two cases with different outcomes |
| title_full_unstemmed | Case report: The value of early application of mNGS technology in the diagnosis and treatment of severe Legionnaires’ disease: reports of two cases with different outcomes |
| title_short | Case report: The value of early application of mNGS technology in the diagnosis and treatment of severe Legionnaires’ disease: reports of two cases with different outcomes |
| title_sort | case report the value of early application of mngs technology in the diagnosis and treatment of severe legionnaires disease reports of two cases with different outcomes |
| topic | legionellosis Legionnaires’ disease case report severe community-acquired pneumonia severe hospital-acquired pneumonia |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1501192/full |
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