Nucleated red blood cells for characterization of systemic inflammatory response syndrome in dogs
Abstract Background Nucleated red blood cells (nRBCs) are increased by disease processes and hematopoietic stress. Objectives To evaluate the utility of nRBCs as a marker of disease severity and prognosis in dogs with systemic inflammatory response syndrome (SIRS). Animals Sixty‐two client‐owned dog...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Journal of Veterinary Internal Medicine |
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| Online Access: | https://doi.org/10.1111/jvim.17246 |
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| author | ARom Cho Hyeona Bae Youngju Kim Yeseul Jeon Rankyung Jung Minji Kim Minjeong Kang Sumin Cha Kyu‐Woan Cho Dong‐In Jung Jinho Park DoHyeon Yu |
| author_facet | ARom Cho Hyeona Bae Youngju Kim Yeseul Jeon Rankyung Jung Minji Kim Minjeong Kang Sumin Cha Kyu‐Woan Cho Dong‐In Jung Jinho Park DoHyeon Yu |
| author_sort | ARom Cho |
| collection | DOAJ |
| description | Abstract Background Nucleated red blood cells (nRBCs) are increased by disease processes and hematopoietic stress. Objectives To evaluate the utility of nRBCs as a marker of disease severity and prognosis in dogs with systemic inflammatory response syndrome (SIRS). Animals Sixty‐two client‐owned dogs met the criteria of SIRS without anemia. Methods nRBC‐positive (nRBCs: ≥5/500, n = 32) and nRBC‐negative (nRBCs: <5/500, n = 30) dogs were classified, and clinicopathological data, Acute Patient Physiologic and Laboratory Evaluation (APPLEfast) scores, cytokines, 2‐ and 4‐weeks survival were compared. Results The median WBC (17.63, interquartile range [IQR]: 11.72‐20.24 × 109/L), neutrophils (12.28, IQR: 7.17‐16.88 × 109/L), band neutrophils (1288.5, IQR: 252.5‐2575 cells/μL), serum IL‐6 (731.80, IQR: 299.79‐5522.05 pg/mL), and plasma C‐reactive protein (4.10, IQR: 1.00‐8.58 mg/L) were significantly higher in nRBC‐positive dogs than negative dogs (11.27, IQR: 7.63‐15.13 × 109/L; 7.57, IQR: 4.96‐11.71 × 109/L; 62.5, IQR: 0‐350.25 cells/μL; 232.30, IQR: 99.33‐447.01 pg/mL; 0.40, IQR: 0.10‐3.00 mg/L, respectively; P < .05). The median reticulocyte count (87.95, IQR: 52.45‐130.55 × 103/μL) and serum IL‐3 (40.94, IQR: 29.85‐53.52 ng/L) were also significantly greater in nRBC‐positive dogs than nRBC‐negative dogs (46.00, IQR: 26.43‐68.15 × 103/μL; 25.24, IQR: 21.65‐37.40 ng/L, respectively; P < .01). The presence of circulating nRBCs, but not the reticulocyte count, at admission was predictive of death in dogs with SIRS at 2 weeks (P = .01, AUC: 0.729) and 4 weeks (P = .002, AUC: 0.731). The overall survival time was shorter in nRBC‐positive dogs (95% CI, 47.35‐113.90) than nRBC‐negative dogs (95% CI, 90.92‐135.55; P = .03). Conclusions and Clinical Importance Measuring peripheral nRBCs in dogs with SIRS is rapid and clinically applicable, reflecting disease severity and associated prognosis. |
| format | Article |
| id | doaj-art-508fcce1c8ed4ebd8467baf65851a25c |
| institution | Kabale University |
| issn | 0891-6640 1939-1676 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj-art-508fcce1c8ed4ebd8467baf65851a25c2025-01-27T15:22:40ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762025-01-01391n/an/a10.1111/jvim.17246Nucleated red blood cells for characterization of systemic inflammatory response syndrome in dogsARom Cho0Hyeona Bae1Youngju Kim2Yeseul Jeon3Rankyung Jung4Minji Kim5Minjeong Kang6Sumin Cha7Kyu‐Woan Cho8Dong‐In Jung9Jinho Park10DoHyeon Yu11College of Veterinary Medicine Gyeongsang National University Jinju 52828 Republic of KoreaCollege of Veterinary Medicine Gyeongsang National University Jinju 52828 Republic of KoreaCollege of Veterinary Medicine Gyeongsang National University Jinju 52828 Republic of KoreaCollege of Veterinary Medicine Gyeongsang National University Jinju 52828 Republic of KoreaCollege of Veterinary Medicine Gyeongsang National University Jinju 52828 Republic of KoreaCollege of Veterinary Medicine Gyeongsang National University Jinju 52828 Republic of KoreaCollege of Veterinary Medicine Gyeongsang National University Jinju 52828 Republic of KoreaCollege of Veterinary Medicine Gyeongsang National University Jinju 52828 Republic of KoreaCollege of Veterinary Medicine Gyeongsang National University Jinju 52828 Republic of KoreaCollege of Veterinary Medicine Gyeongsang National University Jinju 52828 Republic of KoreaCollege of Veterinary Medicine Jeonbuk National University Iksan 54596 Republic of KoreaCollege of Veterinary Medicine Gyeongsang National University Jinju 52828 Republic of KoreaAbstract Background Nucleated red blood cells (nRBCs) are increased by disease processes and hematopoietic stress. Objectives To evaluate the utility of nRBCs as a marker of disease severity and prognosis in dogs with systemic inflammatory response syndrome (SIRS). Animals Sixty‐two client‐owned dogs met the criteria of SIRS without anemia. Methods nRBC‐positive (nRBCs: ≥5/500, n = 32) and nRBC‐negative (nRBCs: <5/500, n = 30) dogs were classified, and clinicopathological data, Acute Patient Physiologic and Laboratory Evaluation (APPLEfast) scores, cytokines, 2‐ and 4‐weeks survival were compared. Results The median WBC (17.63, interquartile range [IQR]: 11.72‐20.24 × 109/L), neutrophils (12.28, IQR: 7.17‐16.88 × 109/L), band neutrophils (1288.5, IQR: 252.5‐2575 cells/μL), serum IL‐6 (731.80, IQR: 299.79‐5522.05 pg/mL), and plasma C‐reactive protein (4.10, IQR: 1.00‐8.58 mg/L) were significantly higher in nRBC‐positive dogs than negative dogs (11.27, IQR: 7.63‐15.13 × 109/L; 7.57, IQR: 4.96‐11.71 × 109/L; 62.5, IQR: 0‐350.25 cells/μL; 232.30, IQR: 99.33‐447.01 pg/mL; 0.40, IQR: 0.10‐3.00 mg/L, respectively; P < .05). The median reticulocyte count (87.95, IQR: 52.45‐130.55 × 103/μL) and serum IL‐3 (40.94, IQR: 29.85‐53.52 ng/L) were also significantly greater in nRBC‐positive dogs than nRBC‐negative dogs (46.00, IQR: 26.43‐68.15 × 103/μL; 25.24, IQR: 21.65‐37.40 ng/L, respectively; P < .01). The presence of circulating nRBCs, but not the reticulocyte count, at admission was predictive of death in dogs with SIRS at 2 weeks (P = .01, AUC: 0.729) and 4 weeks (P = .002, AUC: 0.731). The overall survival time was shorter in nRBC‐positive dogs (95% CI, 47.35‐113.90) than nRBC‐negative dogs (95% CI, 90.92‐135.55; P = .03). Conclusions and Clinical Importance Measuring peripheral nRBCs in dogs with SIRS is rapid and clinically applicable, reflecting disease severity and associated prognosis.https://doi.org/10.1111/jvim.17246cytokineserythropoietinnucleated RBCsreticulocytesystemic inflammatory response syndrome (SIRS) |
| spellingShingle | ARom Cho Hyeona Bae Youngju Kim Yeseul Jeon Rankyung Jung Minji Kim Minjeong Kang Sumin Cha Kyu‐Woan Cho Dong‐In Jung Jinho Park DoHyeon Yu Nucleated red blood cells for characterization of systemic inflammatory response syndrome in dogs Journal of Veterinary Internal Medicine cytokines erythropoietin nucleated RBCs reticulocyte systemic inflammatory response syndrome (SIRS) |
| title | Nucleated red blood cells for characterization of systemic inflammatory response syndrome in dogs |
| title_full | Nucleated red blood cells for characterization of systemic inflammatory response syndrome in dogs |
| title_fullStr | Nucleated red blood cells for characterization of systemic inflammatory response syndrome in dogs |
| title_full_unstemmed | Nucleated red blood cells for characterization of systemic inflammatory response syndrome in dogs |
| title_short | Nucleated red blood cells for characterization of systemic inflammatory response syndrome in dogs |
| title_sort | nucleated red blood cells for characterization of systemic inflammatory response syndrome in dogs |
| topic | cytokines erythropoietin nucleated RBCs reticulocyte systemic inflammatory response syndrome (SIRS) |
| url | https://doi.org/10.1111/jvim.17246 |
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